SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 LEU A  38
LEU A  51
VAL A 109
VAL A  68
LEU A  70
 None
 1.19A 1ie9A-2g8sA:
undetectable		 1ie9A-2g8sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 ASP A  67
GLY A 145
GLY A 198
GLN A 197
 None
None
EDO  A3006 ( 4.5A)
EDO  A3006 ( 4.6A)
 0.80A 1jr1B-2g8sA:
undetectable		 1jr1B-2g8sA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 GLY A 130
PRO A 196
VAL A  69
LEU A 140
PHE A 134
 None
 1.06A 2zzmA-2g8sA:
undetectable		 2zzmA-2g8sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 0.95A 3axzA-2g8sA:
undetectable		 3axzA-2g8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 GLU A 220
ASN A 211
ASN A 222
ILE A 193
 CA  A2002 (-2.2A)
None
CA  A2002 ( 4.4A)
None
 1.27A 3kp6A-2g8sA:
undetectable
3kp6B-2g8sA:
undetectable		 3kp6A-2g8sA:
18.80
3kp6B-2g8sA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 ASN A 222
ILE A 193
GLU A 220
ASN A 211
 CA  A2002 ( 4.4A)
None
CA  A2002 (-2.2A)
None
 1.15A 3kp6A-2g8sA:
undetectable
3kp6B-2g8sA:
undetectable		 3kp6A-2g8sA:
18.80
3kp6B-2g8sA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ASP A  73
SER A  77
ARG A  79
 EDO  A3017 (-2.8A)
EDO  A3017 ( 4.6A)
EDO  A3017 ( 4.3A)
 0.99A 3loqA-2g8sA:
undetectable		 3loqA-2g8sA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 GLN A 118
THR A 152
ASN A 147
 None
 0.88A 3v4tE-2g8sA:
undetectable		 3v4tE-2g8sA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ASP A 295
LYS A 296
ASP A 297
 None
 0.69A 4a7tA-2g8sA:
undetectable		 4a7tA-2g8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ASN A  26
LEU A 106
PHE A  22
 None
EDO  A3016 (-4.6A)
EDO  A3020 (-4.7A)
 0.60A 4dajB-2g8sA:
undetectable		 4dajB-2g8sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ARG A 150
TRP A 232
ILE A 246
 None
EDO  A3002 (-4.6A)
None
 1.07A 4mwxA-2g8sA:
9.0		 4mwxA-2g8sA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 5 GLY A 100
LEU A  65
LEU A 132
LEU A  23
 None
None
None
EDO  A3016 ( 4.0A)
 0.74A 4o8fA-2g8sA:
undetectable		 4o8fA-2g8sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 HIS A  27
SER A  77
PHE A  74
ASP A  25
 EDO  A3016 (-2.7A)
EDO  A3017 ( 4.6A)
EDO  A3016 (-4.7A)
None
 1.29A 4odjA-2g8sA:
undetectable		 4odjA-2g8sA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 5 GLN A 149
LEU A 122
SER A 123
ASP A 219
 None
 1.30A 4qtuD-2g8sA:
undetectable		 4qtuD-2g8sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 1.00A 4yvgA-2g8sA:
undetectable		 4yvgA-2g8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 GLU A 212
GLY A 214
GLY A 218
ASP A 219
 EDO  A3002 (-3.3A)
EDO  A3002 (-3.6A)
None
None
 0.81A 5a06D-2g8sA:
undetectable		 5a06D-2g8sA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ASN A  26
LEU A 106
PHE A  22
 None
EDO  A3016 (-4.6A)
EDO  A3020 (-4.7A)
 0.75A 5dsgA-2g8sA:
undetectable		 5dsgA-2g8sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ARG A 323
HIS A  16
ARG A  34
 EDO  A3006 (-4.2A)
EDO  A3025 (-3.8A)
EDO  A3025 (-4.0A)
 0.74A 5iaoC-2g8sA:
undetectable		 5iaoC-2g8sA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ARG A 323
HIS A  16
ARG A  34
 EDO  A3006 (-4.2A)
EDO  A3025 (-3.8A)
EDO  A3025 (-4.0A)
 0.70A 5iaoF-2g8sA:
undetectable		 5iaoF-2g8sA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 ARG A 323
GLY A 291
GLN A 197
LEU A 293
 EDO  A3006 (-4.2A)
None
EDO  A3006 ( 4.6A)
None
 0.96A 5sxqA-2g8sA:
undetectable		 5sxqA-2g8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 ARG A 323
GLY A 291
GLN A 197
LEU A 293
 EDO  A3006 (-4.2A)
None
EDO  A3006 ( 4.6A)
None
 1.00A 5sxtA-2g8sA:
undetectable		 5sxtA-2g8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 ARG A 323
GLY A 291
GLN A 197
LEU A 293
 EDO  A3006 (-4.2A)
None
EDO  A3006 ( 4.6A)
None
 1.00A 5sxtB-2g8sA:
undetectable		 5sxtB-2g8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 1.08A 5wyqA-2g8sA:
undetectable		 5wyqA-2g8sA:
22.49