SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 LEU A  42
HIS A  13
GLY A  49
LEU A 330
ILE A 328
 None
EDO  A1016 ( 3.9A)
None
None
None
 1.25A 1kyvC-2g8yA:
undetectable
1kyvD-2g8yA:
undetectable		 1kyvC-2g8yA:
18.80
1kyvD-2g8yA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 LEU A  42
HIS A  13
GLY A  49
LEU A 330
ILE A 328
 None
EDO  A1016 ( 3.9A)
None
None
None
 1.23A 1kyvD-2g8yA:
undetectable
1kyvE-2g8yA:
undetectable		 1kyvD-2g8yA:
18.80
1kyvE-2g8yA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 LEU A 330
TRP A 335
LEU A 359
PHE A  15
 None
 1.39A 1ru9H-2g8yA:
undetectable
1ru9L-2g8yA:
undetectable		 1ru9H-2g8yA:
20.00
1ru9L-2g8yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 LEU A 330
TRP A 335
LEU A 359
PHE A  15
 None
 1.41A 1rukH-2g8yA:
undetectable
1rukL-2g8yA:
undetectable		 1rukH-2g8yA:
20.00
1rukL-2g8yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 10 SER A 118
HIS A 116
ALA A  93
ALA A  97
ALA A  71
 None
 1.40A 2r2vC-2g8yA:
undetectable
2r2vF-2g8yA:
undetectable
2r2vG-2g8yA:
undetectable		 2r2vC-2g8yA:
7.31
2r2vF-2g8yA:
7.31
2r2vG-2g8yA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 LEU A  83
GLU A  76
LEU A 115
THR A 274
 None
 0.61A 2roxB-2g8yA:
undetectable		 2roxB-2g8yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 HIS A 140
MET A  98
MET A 272
 None
 1.42A 2vj1A-2g8yA:
undetectable		 2vj1A-2g8yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 6 TRP A 127
ARG A 123
ILE A 124
HIS A 120
 None
None
NAD  A1001 (-4.0A)
EDO  A1019 ( 4.1A)
 1.46A 3deuA-2g8yA:
undetectable		 3deuA-2g8yA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.36A 3dqtA-2g8yA:
undetectable
3dqtB-2g8yA:
1.2		 3dqtA-2g8yA:
23.36
3dqtB-2g8yA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 SER A  59
VAL A  57
TRP A  60
PHE A  89
 None
None
1PE  A1021 (-4.1A)
None
 1.40A 3n5tA-2g8yA:
undetectable
3n5tB-2g8yA:
1.6		 3n5tA-2g8yA:
23.86
3n5tB-2g8yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 11 ILE A  38
ALA A  40
SER A 334
ILE A 338
LEU A  12
 None
 1.32A 3qg2B-2g8yA:
undetectable		 3qg2B-2g8yA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 5 HIS A 119
GLN A  66
GLY A  63
SER A  59
 None
 1.13A 4fu8A-2g8yA:
undetectable		 4fu8A-2g8yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.42A 4k5jA-2g8yA:
undetectable
4k5jB-2g8yA:
undetectable		 4k5jA-2g8yA:
23.91
4k5jB-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 ALA A  43
GLN A  91
GLY A  90
 None
 0.62A 4odoC-2g8yA:
0.0		 4odoC-2g8yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 12 LEU A 359
ALA A 360
ILE A  50
LEU A 330
ILE A 328
 None
 0.95A 4pssA-2g8yA:
undetectable		 4pssA-2g8yA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 9 ALA A 182
TYR A  56
ILE A 268
GLY A 122
VAL A 144
 NAD  A1001 (-3.2A)
None
EDO  A1019 ( 4.7A)
NAD  A1001 (-3.9A)
NAD  A1001 (-4.4A)
 1.24A 4r1zA-2g8yA:
undetectable		 4r1zA-2g8yA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.42A 5adlA-2g8yA:
1.0
5adlB-2g8yA:
1.9		 5adlA-2g8yA:
23.91
5adlB-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.44A 5fj3A-2g8yA:
undetectable
5fj3B-2g8yA:
1.3		 5fj3A-2g8yA:
23.91
5fj3B-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 LYS A   3
LEU A 359
ILE A 328
 None
 0.77A 5kc0A-2g8yA:
undetectable		 5kc0A-2g8yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 8 SER A  47
PHE A 188
GLN A 221
MET A 149
 SO4  A1007 (-2.9A)
None
None
EDO  A1019 (-3.8A)
 1.46A 5u6nA-2g8yA:
undetectable		 5u6nA-2g8yA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 VAL A 144
HIS A 120
SER A 184
THR A 162
 NAD  A1001 (-4.4A)
EDO  A1019 ( 4.1A)
None
SO4  A1003 (-3.3A)
 0.92A 5vkqA-2g8yA:
undetectable
5vkqD-2g8yA:
undetectable		 5vkqA-2g8yA:
12.59
5vkqD-2g8yA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		5 / 7 GLY A  85
LEU A 115
ILE A 121
GLY A  90
ILE A 147
 None
 1.20A 5vkqA-2g8yA:
undetectable
5vkqB-2g8yA:
undetectable		 5vkqA-2g8yA:
12.59
5vkqB-2g8yA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.38A 5vv7A-2g8yA:
1.3
5vv7B-2g8yA:
1.3		 5vv7A-2g8yA:
23.91
5vv7B-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		3 / 3 TYR A 126
HIS A  95
MET A  98
 None
 1.07A 6af6A-2g8yA:
undetectable		 6af6A-2g8yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 SER A  59
VAL A  57
TRP A  60
PHE A  89
 None
None
1PE  A1021 (-4.1A)
None
 1.41A 6av7A-2g8yA:
undetectable
6av7B-2g8yA:
0.0		 6av7A-2g8yA:
14.57
6av7B-2g8yA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 5 ARG A  87
GLY A  85
ASN A 117
ASP A  86
 None
 1.39A 6dwjB-2g8yA:
undetectable
6dwjD-2g8yA:
undetectable		 6dwjB-2g8yA:
25.27
6dwjD-2g8yA:
25.27