SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g9b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 PHE A  23
LEU A  78
MET A  58
 None
 0.89A 1mx1D-2g9bA:
2.8		 1mx1D-2g9bA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 7 THR A  84
PHE A  88
SER A   9
LEU A 153
 None
 1.00A 1qcaA-2g9bA:
undetectable		 1qcaA-2g9bA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.42A 1v55N-2g9bA:
undetectable
1v55W-2g9bA:
undetectable		 1v55N-2g9bA:
16.24
1v55W-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 8 SER A 156
LEU A 178
LEU A 241
LEU A 252
 None
 0.95A 2bfpC-2g9bA:
undetectable		 2bfpC-2g9bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 11 LEU A  31
LEU A  39
GLN A  37
ILE A  73
PHE A  61
 None
 1.26A 2q6hA-2g9bA:
undetectable		 2q6hA-2g9bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 11 LEU A  31
LEU A  39
GLN A  37
ILE A  73
PHE A  61
 None
 1.26A 2qeiA-2g9bA:
undetectable		 2qeiA-2g9bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 GLY A 259
ASP A 260
SER A 257
 None
 0.74A 2qhfA-2g9bA:
undetectable		 2qhfA-2g9bA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ALA A   2
GLU A  42
LEU A   6
LEU A  82
ILE A  75
 None
 1.32A 2uxpA-2g9bA:
undetectable		 2uxpA-2g9bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.46A 3abkA-2g9bA:
undetectable
3abkJ-2g9bA:
undetectable		 3abkA-2g9bA:
16.24
3abkJ-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.43A 3abmN-2g9bA:
undetectable
3abmW-2g9bA:
undetectable		 3abmN-2g9bA:
16.24
3abmW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.45A 3asoN-2g9bA:
undetectable
3asoW-2g9bA:
undetectable		 3asoN-2g9bA:
16.24
3asoW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 6 LEU A  39
PHE A  23
ILE A  19
ALA A   2
 None
 0.96A 3mdrA-2g9bA:
undetectable		 3mdrA-2g9bA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 TYR A 248
LEU A 218
ARG A 249
 None
 0.76A 3sufB-2g9bA:
undetectable		 3sufB-2g9bA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 6 LEU A  43
GLN A  37
LEU A  36
GLU A  35
 None
 1.09A 4nc3A-2g9bA:
2.1		 4nc3A-2g9bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 7 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.47A 5b1bN-2g9bA:
2.2
5b1bW-2g9bA:
undetectable		 5b1bN-2g9bA:
16.24
5b1bW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 7 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.45A 5b3sN-2g9bA:
undetectable
5b3sW-2g9bA:
undetectable		 5b3sN-2g9bA:
16.24
5b3sW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 7 LYS A 133
LEU A 130
ILE A 118
LEU A 151
 None
 1.06A 5fxtA-2g9bA:
undetectable		 5fxtA-2g9bA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 PHE A 117
ASP A 155
LEU A 127
 None
 0.72A 5uhbC-2g9bA:
undetectable		 5uhbC-2g9bA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 PHE A 117
ASP A 155
LEU A 127
 None
 0.74A 5uhcC-2g9bA:
undetectable		 5uhcC-2g9bA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2g9b CALBINDIN
(Rattus
norvegicus) 		4 / 8 VAL A  81
LEU A  78
TYR A  65
ILE A  40
 None
 0.90A 5y1yA-2g9bA:
undetectable		 5y1yA-2g9bA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 10 LEU A 241
ILE A 118
LEU A 123
LEU A 170
ALA A 168
 None
 1.24A 5y7pB-2g9bA:
undetectable		 5y7pB-2g9bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 10 LEU A 241
ILE A 118
LEU A 123
LEU A 170
ALA A 168
 None
 1.22A 5y7pD-2g9bA:
undetectable		 5y7pD-2g9bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 10 LEU A 241
ILE A 118
LEU A 123
LEU A 170
ALA A 168
 None
 1.22A 5y7pH-2g9bA:
undetectable		 5y7pH-2g9bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2g9b CALBINDIN
(Rattus
norvegicus) 		5 / 8 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.44A 5zcpN-2g9bA:
undetectable
5zcpW-2g9bA:
undetectable		 5zcpN-2g9bA:
16.24
5zcpW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g9b CALBINDIN
(Rattus
norvegicus) 		3 / 3 LEU A  54
ASN A  38
LEU A  78
 None
 0.68A 6exiA-2g9bA:
undetectable		 6exiA-2g9bA:
13.41