SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  87
LEU A 245
VAL A 104
GLY A 153
ARG A 154
 None
 1.33A 1y4lB-2g9iA:
undetectable		 1y4lB-2g9iA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  23
SER A  26
LEU A  11
PRO A  12
 None
 0.75A 3onnA-2g9iA:
undetectable		 3onnA-2g9iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		5 / 11 VAL A  42
PHE A  99
GLY A 166
MET A 229
ILE A 147
 None
 1.19A 3owxA-2g9iA:
undetectable
3owxB-2g9iA:
undetectable		 3owxA-2g9iA:
20.38
3owxB-2g9iA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		5 / 8 GLY A 162
ALA A 199
ASP A 196
GLY A 166
ILE A 148
 None
 1.40A 3so9A-2g9iA:
undetectable		 3so9A-2g9iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 148
ILE A 165
PHE A  99
GLY A 107
 None
 0.65A 4ac9C-2g9iA:
undetectable		 4ac9C-2g9iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 166
MET A 229
ILE A 147
VAL A  42
PHE A  99
 None
 1.14A 4fglA-2g9iA:
undetectable
4fglB-2g9iA:
undetectable		 4fglA-2g9iA:
19.15
4fglB-2g9iA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 169
GLY A 225
ILE A 167
ALA A 172
ALA A 129
 None
 1.22A 4kicA-2g9iA:
undetectable		 4kicA-2g9iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 6 ASN A  57
GLU A  74
GLU A  55
GLU A  81
 None
 1.33A 4mi4A-2g9iA:
undetectable		 4mi4A-2g9iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A  57
GLU A  74
GLU A  55
GLU A  81
 None
 1.31A 4mj8C-2g9iA:
undetectable		 4mj8C-2g9iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 8 PRO A  72
LEU A  53
VAL A 113
LEU A 118
 None
 1.02A 4pwdA-2g9iA:
undetectable		 4pwdA-2g9iA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 148
PHE A 201
SER A 168
ASP A 196
 None
 1.29A 4rzvB-2g9iA:
undetectable		 4rzvB-2g9iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		3 / 3 VAL A 218
LEU A 221
VAL A   3
 None
 0.62A 4wq4A-2g9iA:
undetectable		 4wq4A-2g9iA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 6 ASP A  34
ARG A 219
GLY A 220
GLU A   4
 None
 1.01A 5cdqA-2g9iA:
undetectable
5cdqC-2g9iA:
undetectable
5cdqD-2g9iA:
undetectable		 5cdqA-2g9iA:
21.50
5cdqC-2g9iA:
21.50
5cdqD-2g9iA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		4 / 8 ALA A 129
VAL A 146
LEU A  36
VAL A  42
 None
 0.84A 5nujA-2g9iA:
undetectable		 5nujA-2g9iA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 163
ASP A 150
LEU A  36
 None
 0.81A 5uhbC-2g9iA:
undetectable		 5uhbC-2g9iA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2g9i F420-0:GAMMA-GLUTAMY
L LIGASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  29
PHE A   6
ARG A 219
 None
 1.07A 5y9yA-2g9iA:
undetectable		 5y9yA-2g9iA:
20.92