SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 8 ASN A  38
LEU A  39
LEU A  64
LYS A  69
 None
None
None
MLY  A  68 ( 3.2A)
 1.11A 1hk2A-2g9nA:
undetectable		 1hk2A-2g9nA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 5 GLY A  69
ILE A  67
VAL A  72
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.17A 1rs7A-2g9nA:
undetectable		 1rs7A-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 5 GLY A  69
ILE A  67
VAL A 210
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.21A 1rs7A-2g9nA:
undetectable		 1rs7A-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 6 GLY A  69
ILE A  67
VAL A  72
SER A  89
 MLY  A  68 ( 2.3A)
MLY  A  68 ( 3.9A)
None
None
 1.09A 1rs7B-2g9nA:
undetectable		 1rs7B-2g9nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 6 LEU A 211
PHE A 200
ILE A 196
ALA A 184
 None
None
MLY  A 193 ( 4.1A)
None
 1.06A 2j5mA-2g9nA:
undetectable		 2j5mA-2g9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		3 / 3 LEU A  44
TYR A  48
GLY A  51
 None
 0.60A 2ocuA-2g9nA:
undetectable		 2ocuA-2g9nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		5 / 12 LEU A 181
GLN A  93
PHE A 200
LEU A 203
VAL A 120
 None
None
None
MLY  A 202 ( 4.2A)
None
 1.44A 2w8yA-2g9nA:
undetectable		 2w8yA-2g9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		5 / 9 ILE A 199
ILE A 196
TYR A 197
ALA A 184
LEU A 181
 None
MLY  A 193 ( 4.1A)
MLY  A 193 ( 3.9A)
None
None
 1.09A 3ozvB-2g9nA:
undetectable		 3ozvB-2g9nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		3 / 3 TYR A  48
ASP A  32
ASP A  35
 None
MLY  A  54 ( 3.5A)
None
 0.66A 3r24A-2g9nA:
3.4		 3r24A-2g9nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		3 / 3 LYS A  83
SER A  56
GLN A  59
 MLY  A  82 ( 3.0A)
None
None
 0.93A 3si7A-2g9nA:
3.9		 3si7A-2g9nA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 8 ARG A 141
ARG A 161
TYR A 170
GLU A 143
 None
 1.43A 3zmdA-2g9nA:
undetectable
3zmdB-2g9nA:
undetectable		 3zmdA-2g9nA:
22.32
3zmdB-2g9nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		3 / 3 GLY A 160
PRO A 159
ALA A 107
 None
 0.55A 4qn9B-2g9nA:
undetectable		 4qn9B-2g9nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 6 PRO A  55
ILE A  30
VAL A 236
THR A  85
 MLY  A  54 ( 2.6A)
None
MLY  A 237 ( 3.0A)
MLY  A  82 ( 3.9A)
 1.09A 4xe5A-2g9nA:
undetectable		 4xe5A-2g9nA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens) 		4 / 8 ILE A 116
ALA A 103
VAL A 180
VAL A 120
 None
 0.68A 5ecnD-2g9nA:
undetectable		 5ecnD-2g9nA:
16.84