SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ga8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 190
PRO A 187
ASP A 162
LEU A 268
TYR A 269
 None
 1.47A 1e7wB-2ga8A:
1.5		 1e7wB-2ga8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 190
PRO A 187
ASP A 162
LEU A 268
TYR A 269
 None
 1.44A 1p33D-2ga8A:
undetectable		 1p33D-2ga8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 347
LEU A  44
ILE A 262
ASP A  10
 None
CME  A  45 ( 3.7A)
None
None
 0.86A 1uwjA-2ga8A:
undetectable		 1uwjA-2ga8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 350
ILE A 342
TYR A 281
LEU A   7
 None
 1.14A 3adsA-2ga8A:
undetectable		 3adsA-2ga8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  11
LEU A  15
ILE A 155
ALA A 156
 None
None
None
CME  A  45 ( 3.8A)
 0.97A 3n8yB-2ga8A:
undetectable		 3n8yB-2ga8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 ASP A  16
ILE A 262
VAL A  27
TYR A 293
 None
 1.09A 3p6hA-2ga8A:
undetectable		 3p6hA-2ga8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  25
LEU A 202
ILE A  48
ILE A 264
VAL A 159
 None
None
CME  A  45 ( 4.1A)
None
None
 0.96A 3w68D-2ga8A:
undetectable		 3w68D-2ga8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 290
LEU A 270
LEU A 271
ILE A 350
ILE A 295
 None
 1.26A 4j24C-2ga8A:
undetectable		 4j24C-2ga8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 290
LEU A 270
LEU A 271
ILE A 350
ILE A 295
 None
 1.30A 4j26B-2ga8A:
undetectable		 4j26B-2ga8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 291
LEU A 202
ASN A  22
 None
 0.74A 4otwA-2ga8A:
undetectable		 4otwA-2ga8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  30
ASP A 336
ILE A 337
GLY A 334
VAL A 306
 None
None
None
None
BME  A 501 ( 4.3A)
 1.12A 4y8wB-2ga8A:
undetectable		 4y8wB-2ga8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  49
LEU A  15
PHE A 259
 CME  A  45 ( 3.6A)
None
None
 0.72A 5dsgA-2ga8A:
undetectable		 5dsgA-2ga8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 239
ILE A 134
ILE A 201
LEU A 202
VAL A 159
 None
 1.00A 5uvmB-2ga8A:
undetectable		 5uvmB-2ga8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 2ga8 HYPOTHETICAL 39.9
KDA PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 THR A 130
GLY A 129
GLY A 128
TYR A 111
GLU A  89
 None
 1.33A 6gnfA-2ga8A:
undetectable		 6gnfA-2ga8A:
20.33