SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 8 PHE D 324
HIS D 320
LEU D 282
THR D 279
 None
 0.73A 1azmA-2gafD:
undetectable		 1azmA-2gafD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 8 PHE D 324
HIS D 320
LEU D 282
THR D 279
 None
 0.76A 1bzmA-2gafD:
undetectable		 1bzmA-2gafD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 6 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.94A 1mt1A-2gafD:
undetectable
1mt1F-2gafD:
undetectable		 1mt1A-2gafD:
9.11
1mt1F-2gafD:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 6 ILE D 343
LEU D 373
ASP D 369
LEU D 366
 None
 0.94A 1mt1B-2gafD:
undetectable
1mt1C-2gafD:
undetectable		 1mt1B-2gafD:
12.62
1mt1C-2gafD:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.95A 1n13I-2gafD:
undetectable
1n13L-2gafD:
undetectable		 1n13I-2gafD:
9.11
1n13L-2gafD:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 5 LEU D 313
PHE D 289
MET D 145
SER D 144
 None
 1.29A 1wrlC-2gafD:
undetectable		 1wrlC-2gafD:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 12 LEU D 237
ILE D 234
HIS D 250
ASP D 202
ASP D 204
 None
 1.03A 1zz1B-2gafD:
undetectable
1zz1C-2gafD:
undetectable		 1zz1B-2gafD:
20.56
1zz1C-2gafD:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 12 PHE D  52
VAL D  56
ASN D 228
ILE D 229
LEU D 104
 None
 1.28A 2ft9A-2gafD:
undetectable		 2ft9A-2gafD:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 11 LEU D 439
MET D 333
MET D 331
LEU D 298
MET D 309
 None
 1.08A 2n27A-2gafD:
0.8		 2n27A-2gafD:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		3 / 3 THR D 345
ASP D 369
SER D 367
 None
 0.77A 2nxeA-2gafD:
undetectable		 2nxeA-2gafD:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		3 / 3 THR D 345
ASP D 369
SER D 367
 None
 0.77A 2nxeB-2gafD:
undetectable		 2nxeB-2gafD:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 ILE D 205
SER D 254
PHE D 213
ILE D 111
 None
 1.11A 2q6hA-2gafD:
undetectable		 2q6hA-2gafD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 ILE D 205
SER D 254
PHE D 213
ILE D 111
 None
 1.10A 2qb4A-2gafD:
undetectable		 2qb4A-2gafD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 ILE D 343
LEU D 373
ASP D 369
LEU D 366
 None
 1.00A 2qqcB-2gafD:
undetectable
2qqcC-2gafD:
undetectable		 2qqcB-2gafD:
12.68
2qqcC-2gafD:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.98A 2qqcA-2gafD:
undetectable
2qqcF-2gafD:
undetectable		 2qqcA-2gafD:
9.87
2qqcF-2gafD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.92A 2qqcG-2gafD:
undetectable
2qqcJ-2gafD:
undetectable		 2qqcG-2gafD:
9.87
2qqcJ-2gafD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 7 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.97A 2qqcI-2gafD:
undetectable
2qqcL-2gafD:
undetectable		 2qqcI-2gafD:
9.87
2qqcL-2gafD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		3 / 3 TYR D 108
VAL D  56
THR D 109
 None
 0.88A 2ygnA-2gafD:
undetectable		 2ygnA-2gafD:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 12 LEU D 112
LEU D 115
VAL D 168
MET D 172
PHE D  52
 None
 1.30A 2yloA-2gafD:
undetectable		 2yloA-2gafD:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		3 / 3 GLU D 363
TYR D 399
SER D 401
 None
 0.82A 4at0A-2gafD:
undetectable		 4at0A-2gafD:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 6 ILE D 229
THR D 225
VAL D 242
ASP D 202
 None
 1.16A 4iaqA-2gafD:
2.5		 4iaqA-2gafD:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 8 TYR D 315
HIS D 320
LEU D 283
LEU D 439
 None
 1.10A 4jtrA-2gafD:
undetectable		 4jtrA-2gafD:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 11 HIS D 250
PHE D 255
ASP D 202
ASP D 204
TYR D 186
 None
 1.48A 4qa0B-2gafD:
undetectable		 4qa0B-2gafD:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 12 TYR D 186
ASN D 386
LEU D 237
LEU D 206
PHE D 280
 None
 1.12A 4rtbA-2gafD:
undetectable		 4rtbA-2gafD:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		4 / 8 GLN D 207
LEU D 115
LEU D 112
THR D 107
 None
 1.14A 5hs6A-2gafD:
undetectable		 5hs6A-2gafD:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT
(Vaccinia
virus) 		5 / 12 TYR D 351
PHE D 352
ALA D 417
LEU D 442
LEU D 425
 None
 1.15A 6aybA-2gafD:
undetectable		 6aybA-2gafD:
21.25