SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 161
GLU A 160
GLU A 159
 None
 0.56A 1eqbD-2gamA:
undetectable		 1eqbD-2gamA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 SER A 161
GLU A 160
GLU A 159
 None
 0.55A 1eqbB-2gamA:
undetectable		 1eqbB-2gamA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		5 / 11 ALA A 324
GLY A 285
GLU A 320
ASN A 215
TYR A 295
 None
None
NGA  A 502 (-2.9A)
None
None
 1.39A 1n6cA-2gamA:
undetectable		 1n6cA-2gamA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		5 / 11 ALA A 349
ALA A 351
TYR A 212
GLN A 327
PHE A 336
 None
 1.06A 3bszF-2gamA:
undetectable		 3bszF-2gamA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		4 / 6 CYH A  59
THR A  60
CYH A 413
ILE A  70
 None
 1.26A 3w9tB-2gamA:
undetectable		 3w9tB-2gamA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 ASN A 250
GLU A 253
ARG A 254
 NGA  A 502 (-3.8A)
None
NGA  A 502 (-3.0A)
 0.90A 3wxoA-2gamA:
undetectable		 3wxoA-2gamA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		4 / 6 HIS A 376
GLU A 360
ASP A 387
PRO A 371
 None
 1.38A 4apjA-2gamA:
undetectable
4apjP-2gamA:
undetectable		 4apjA-2gamA:
20.17
4apjP-2gamA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		4 / 5 LEU A 139
VAL A 176
VAL A 154
ARG A  98
 None
 0.84A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		4 / 5 VAL A 176
VAL A 154
TYR A 125
ARG A  98
 None
 1.05A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 MET A  96
ASP A 137
ARG A  87
 None
 1.01A 5z6jA-2gamA:
undetectable		 5z6jA-2gamA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 MET A  96
ASP A 137
ARG A  87
 None
 1.20A 5z6kA-2gamA:
undetectable		 5z6kA-2gamA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 LEU A 282
SER A 284
PHE A 321
 None
 0.54A 6fgcA-2gamA:
undetectable		 6fgcA-2gamA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		4 / 7 GLY A 386
PHE A 383
VAL A 406
LYS A 355
 None
 1.02A 6hu9S-2gamA:
undetectable
6hu9q-2gamA:
0.0		 6hu9S-2gamA:
13.98
6hu9q-2gamA:
13.70