SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		4 / 4 VAL A  21
LEU A  81
ILE A 106
LEU A  98
 None
 0.98A 2byoA-2gasA:
undetectable		 2byoA-2gasA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		4 / 6 ARG A 138
VAL A 128
LEU A 126
ALA A 133
 None
 1.08A 2e1qA-2gasA:
undetectable		 2e1qA-2gasA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 VAL A 128
ASP A 129
GLU A 123
 None
 0.65A 2qeuA-2gasA:
undetectable		 2qeuA-2gasA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 VAL A 128
ASP A 129
GLU A 123
 None
 0.64A 2qeuC-2gasA:
undetectable		 2qeuC-2gasA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 160
ASP A 127
ASP A 291
 None
 0.85A 3ou7B-2gasA:
4.6		 3ou7B-2gasA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE A 110
ALA A 113
ALA A  84
LEU A  81
LEU A  10
 None
 1.01A 3uvvA-2gasA:
undetectable		 3uvvA-2gasA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE A 110
ALA A 113
ALA A  84
LEU A  81
LEU A  10
 None
 1.15A 4lnwA-2gasA:
undetectable		 4lnwA-2gasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		5 / 11 LEU A  10
THR A  80
ALA A  84
VAL A  88
ILE A  85
 None
 1.10A 4x20D-2gasA:
6.9		 4x20D-2gasA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 ARG A 149
TYR A 158
GLU A 152
 None
 0.65A 4zzbE-2gasA:
undetectable		 4zzbE-2gasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 288
TYR A 307
SER A 299
 None
 0.90A 5iktB-2gasA:
undetectable		 5iktB-2gasA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 199
TYR A 277
GLN A 281
 None
 1.06A 5jsdA-2gasA:
undetectable
5jsdB-2gasA:
undetectable		 5jsdA-2gasA:
17.51
5jsdB-2gasA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 199
TYR A 277
GLN A 281
 None
 1.06A 5jsdB-2gasA:
undetectable
5jsdC-2gasA:
undetectable		 5jsdB-2gasA:
17.51
5jsdC-2gasA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		4 / 6 GLY A  11
LEU A  10
VAL A 205
PHE A 120
 None
 0.85A 6h7lA-2gasA:
undetectable		 6h7lA-2gasA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2gas ISOFLAVONE REDUCTASE
(Medicago
sativa) 		4 / 6 GLY A  11
LEU A  10
VAL A 205
PHE A 120
 None
 0.85A 6h7lB-2gasA:
undetectable		 6h7lB-2gasA:
14.24