SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gau'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 7 LEU A 161
THR A 228
LEU A 225
THR A 200
 None
 0.77A 4z90A-2gauA:
undetectable
4z90B-2gauA:
undetectable
4z90C-2gauA:
undetectable
4z90D-2gauA:
undetectable
4z90E-2gauA:
undetectable		 4z90A-2gauA:
21.74
4z90B-2gauA:
21.74
4z90C-2gauA:
21.74
4z90D-2gauA:
21.74
4z90E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 7 LEU A 225
LEU A 210
THR A 200
THR A 228
 None
 0.74A 4z90A-2gauA:
undetectable
4z90B-2gauA:
undetectable
4z90C-2gauA:
undetectable
4z90D-2gauA:
undetectable
4z90E-2gauA:
undetectable		 4z90A-2gauA:
21.74
4z90B-2gauA:
21.74
4z90C-2gauA:
21.74
4z90D-2gauA:
21.74
4z90E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 7 LEU A 225
LEU A 210
THR A 203
THR A 228
 None
 0.93A 4z90A-2gauA:
undetectable
4z90B-2gauA:
undetectable
4z90C-2gauA:
undetectable
4z90D-2gauA:
undetectable
4z90E-2gauA:
undetectable		 4z90A-2gauA:
21.74
4z90B-2gauA:
21.74
4z90C-2gauA:
21.74
4z90D-2gauA:
21.74
4z90E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 8 LEU A 210
THR A 200
THR A 228
LEU A 225
 None
 0.78A 4z90F-2gauA:
undetectable
4z90G-2gauA:
undetectable
4z90H-2gauA:
undetectable
4z90I-2gauA:
undetectable
4z90J-2gauA:
undetectable		 4z90F-2gauA:
21.74
4z90G-2gauA:
21.74
4z90H-2gauA:
21.74
4z90I-2gauA:
21.74
4z90J-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		5 / 10 LEU A 157
THR A 228
LEU A 225
LEU A 210
THR A 200
 None
 0.86A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		5 / 10 LEU A 210
THR A 200
LEU A 157
THR A 228
LEU A 225
 None
 0.82A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		5 / 10 LEU A 210
THR A 200
LEU A 201
LEU A 157
THR A 228
 None
 1.00A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		5 / 10 LEU A 225
LEU A 210
THR A 200
LEU A 157
THR A 228
 None
 0.87A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		5 / 10 THR A 200
LEU A 157
THR A 228
LEU A 225
LEU A 210
 None
 0.90A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		6 / 10 THR A 228
LEU A 225
LEU A 210
THR A 200
LEU A 201
LEU A 157
 None
 1.13A 4z91A-2gauA:
0.0
4z91B-2gauA:
0.0
4z91C-2gauA:
0.0
4z91D-2gauA:
0.0
4z91E-2gauA:
0.0		 4z91A-2gauA:
21.74
4z91B-2gauA:
21.74
4z91C-2gauA:
21.74
4z91D-2gauA:
21.74
4z91E-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 7 LEU A 157
THR A 228
LEU A 210
THR A 200
 None
 0.80A 4z91F-2gauA:
undetectable
4z91G-2gauA:
undetectable
4z91H-2gauA:
undetectable
4z91I-2gauA:
undetectable
4z91J-2gauA:
undetectable		 4z91F-2gauA:
21.74
4z91G-2gauA:
21.74
4z91H-2gauA:
21.74
4z91I-2gauA:
21.74
4z91J-2gauA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gau TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Porphyromonas
gingivalis) 		4 / 7 LEU A 225
THR A 200
LEU A 157
THR A 228
 None
 0.93A 4z91F-2gauA:
undetectable
4z91G-2gauA:
undetectable
4z91H-2gauA:
undetectable
4z91I-2gauA:
undetectable
4z91J-2gauA:
undetectable		 4z91F-2gauA:
21.74
4z91G-2gauA:
21.74
4z91H-2gauA:
21.74
4z91I-2gauA:
21.74
4z91J-2gauA:
21.74