SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 TYR A  80
VAL A 208
ILE A 207
LEU A 277
 None
 0.94A 1j96A-2gb3A:
undetectable		 1j96A-2gb3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 PHE A 209
ALA A 316
ILE A 319
PRO A 313
 None
 1.08A 1oniH-2gb3A:
undetectable
1oniI-2gb3A:
undetectable		 1oniH-2gb3A:
15.22
1oniI-2gb3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 ALA A 134
LEU A 138
ILE A 103
VAL A 167
ILE A 166
 None
 1.36A 2uxpA-2gb3A:
undetectable		 2uxpA-2gb3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A  45
SER A 235
PHE A 286
 None
 0.83A 3d4sA-2gb3A:
undetectable		 3d4sA-2gb3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ALA A 255
ARG A 262
LEU A 258
ALA A 259
VAL A 136
 None
 1.04A 3dzyA-2gb3A:
undetectable		 3dzyA-2gb3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.93A 4k8cA-2gb3A:
3.1		 4k8cA-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.91A 4kahA-2gb3A:
3.0		 4kahA-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.92A 4kahB-2gb3A:
2.9		 4kahB-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.94A 4kanA-2gb3A:
3.0		 4kanA-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.93A 4kanB-2gb3A:
2.8		 4kanB-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.90A 4kbeA-2gb3A:
3.1		 4kbeA-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.91A 4kbeB-2gb3A:
3.1		 4kbeB-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.94A 4lbgA-2gb3A:
3.0		 4lbgA-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A 215
TYR A  80
PRO A 171
 None
 0.94A 4lbgB-2gb3A:
2.9		 4lbgB-2gb3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 4 ILE A 252
ASN A 248
ILE A 110
VAL A 109
 None
 1.20A 4uy87-2gb3A:
undetectable		 4uy87-2gb3A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 TYR A  80
VAL A 208
ILE A 207
LEU A 277
 None
 0.83A 4xo7A-2gb3A:
undetectable		 4xo7A-2gb3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 LEU A  72
GLY A  68
ALA A  75
LEU A 277
GLY A 272
 None
 1.20A 4zauA-2gb3A:
undetectable		 4zauA-2gb3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A  98
GLY A  99
VAL A  95
ASP A 228
 LLP  A 232 ( 3.4A)
LLP  A 232 ( 3.8A)
None
None
 0.78A 5f8yA-2gb3A:
undetectable		 5f8yA-2gb3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PRO A  90
ARG A  73
GLU A  74
 None
 0.71A 5j6hA-2gb3A:
undetectable		 5j6hA-2gb3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LEU A 168
LEU A 120
TYR A 186
LEU A 198
 None
 0.64A 5jqbA-2gb3A:
undetectable
5jqbB-2gb3A:
undetectable		 5jqbA-2gb3A:
20.72
5jqbB-2gb3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A  64
TYR A  63
TYR A  62
 None
 0.79A 5lakA-2gb3A:
undetectable
5lakI-2gb3A:
undetectable		 5lakA-2gb3A:
20.91
5lakI-2gb3A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 SER A  64
TYR A  63
TYR A  62
 None
 0.83A 5lakC-2gb3A:
undetectable
5lakJ-2gb3A:
undetectable		 5lakC-2gb3A:
20.91
5lakJ-2gb3A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 320
PRO A  15
ARG A  17
 None
 0.73A 5nd7B-2gb3A:
undetectable		 5nd7B-2gb3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 MET A 335
PHE A 331
ILE A 367
LEU A 323
ALA A 328
 None
 1.46A 5oy0b-2gb3A:
undetectable		 5oy0b-2gb3A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 4 ASP A 228
ALA A 236
SER A 273
PHE A 284
 None
 1.26A 6cm4A-2gb3A:
0.0		 6cm4A-2gb3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 ASP A 228
VAL A 203
SER A 205
VAL A 241
TYR A  79
 None
 1.21A 6dryA-2gb3A:
undetectable		 6dryA-2gb3A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 ASP A 228
VAL A 203
SER A 205
VAL A 241
TYR A  80
 None
 1.31A 6dryA-2gb3A:
undetectable		 6dryA-2gb3A:
24.35