SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 ALA A  68
ILE A  69
PHE A  94
LEU A  48
LEU A  44
 SAH  A 300 ( 4.4A)
None
None
None
None
 1.11A 1dtlA-2gb4A:
undetectable		 1dtlA-2gb4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 230
CYH A 211
ALA A 178
ALA A 217
HIS A  47
 None
 1.24A 3b0wB-2gb4A:
undetectable		 3b0wB-2gb4A:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		6 / 6 PHE A  35
ARG A 147
GLY A 148
ALA A 152
LEU A 180
PRO A 191
 SAH  A 300 (-3.4A)
SAH  A 300 (-3.9A)
SAH  A 300 (-3.9A)
SAH  A 300 ( 3.9A)
None
None
 0.15A 3bgdA-2gb4A:
42.2		 3bgdA-2gb4A:
95.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		6 / 6 HIS A  47
THR A  50
PHE A  51
GLN A 174
LEU A 212
LEU A 236
 None
 0.26A 3bgdA-2gb4A:
33.0		 3bgdA-2gb4A:
95.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		4 / 8 ARG A 147
GLY A 148
VAL A 151
ARG A 221
 SAH  A 300 (-3.9A)
SAH  A 300 (-3.9A)
None
None
 1.03A 3bgdB-2gb4A:
42.0		 3bgdB-2gb4A:
95.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		7 / 8 PHE A  35
ARG A 147
GLY A 148
VAL A 151
LEU A 180
PRO A 191
TRP A 225
 SAH  A 300 (-3.4A)
SAH  A 300 (-3.9A)
SAH  A 300 (-3.9A)
None
None
None
None
 0.41A 3bgdB-2gb4A:
42.0		 3bgdB-2gb4A:
95.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		7 / 7 HIS A  47
THR A  50
PHE A  51
GLN A 174
LEU A 176
LEU A 212
LEU A 236
 None
 0.31A 3bgdB-2gb4A:
42.0		 3bgdB-2gb4A:
95.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		4 / 8 VAL A 194
HIS A 158
PHE A 203
PRO A  63
 None
 1.34A 3v35A-2gb4A:
undetectable		 3v35A-2gb4A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 GLY A 121
PHE A  94
PHE A  95
LEU A 100
 None
 0.81A 3v7pA-2gb4A:
undetectable		 3v7pA-2gb4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 HIS A  41
GLU A  70
TRP A 145
 None
 1.14A 5odiD-2gb4A:
undetectable		 5odiD-2gb4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 HIS A  41
GLU A  70
TRP A 145
 None
 1.18A 5odqD-2gb4A:
undetectable		 5odqD-2gb4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 HIS A  41
GLU A  70
TRP A 145
 None
 1.18A 5odrD-2gb4A:
undetectable		 5odrD-2gb4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 9 PRO A 191
LEU A 180
LEU A 227
ASP A  10
SER A 181
 None
 1.45A 5tixA-2gb4A:
0.1		 5tixA-2gb4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 10 PHE A  61
GLY A 139
ILE A 138
ILE A 130
ILE A 164
 None
None
None
SAH  A 300 (-4.5A)
None
 1.07A 6ebpD-2gb4A:
undetectable		 6ebpD-2gb4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 11 PHE A  61
GLY A 139
ILE A 138
ILE A 130
ILE A 164
 None
None
None
SAH  A 300 (-4.5A)
None
 1.07A 6ebzB-2gb4A:
undetectable		 6ebzB-2gb4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 11 PHE A  61
GLY A 139
ILE A 138
ILE A 130
ILE A 164
 None
None
None
SAH  A 300 (-4.5A)
None
 1.06A 6ebzD-2gb4A:
undetectable		 6ebzD-2gb4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		5 / 11 PHE A  61
GLY A 139
ILE A 138
ILE A 130
ILE A 164
 None
None
None
SAH  A 300 (-4.5A)
None
 1.08A 6gp2A-2gb4A:
undetectable		 6gp2A-2gb4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gb4 THIOPURINE
S-METHYLTRANSFERASE
(Mus
musculus) 		3 / 3 ARG A 147
PHE A 192
PHE A  35
 SAH  A 300 (-3.9A)
None
SAH  A 300 (-3.4A)
 1.05A 6nknC-2gb4A:
undetectable
6nknJ-2gb4A:
undetectable		 6nknC-2gb4A:
18.38
6nknJ-2gb4A:
13.10