SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 8 PHE A 147
MET A  40
PHE A 311
LEU A 168
 None
 1.23A 1ea1A-2gbxA:
undetectable		 1ea1A-2gbxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 4 LEU A 190
ILE A 370
ARG A  17
TRP A  21
 None
 1.42A 1ie9A-2gbxA:
0.0		 1ie9A-2gbxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		3 / 3 THR A  72
GLU A 140
ASP A 159
 None
 0.69A 1nt2A-2gbxA:
undetectable		 1nt2A-2gbxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		5 / 11 GLY A 162
GLY A 249
HIS A 248
HIS A 246
THR A 244
 None
 1.14A 1utdL-2gbxA:
undetectable
1utdV-2gbxA:
undetectable		 1utdL-2gbxA:
10.21
1utdV-2gbxA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		3 / 3 ARG A 286
SER A 156
TYR A 160
 None
 0.76A 1x70A-2gbxA:
undetectable		 1x70A-2gbxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		5 / 11 GLY A 292
LEU A 291
TYR A 396
TYR A 167
PHE A 242
 None
 1.48A 2h21B-2gbxA:
undetectable		 2h21B-2gbxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		5 / 11 GLY A 292
LEU A 291
TYR A 396
TYR A 167
PHE A 242
 None
 1.46A 2h21C-2gbxA:
undetectable		 2h21C-2gbxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		5 / 12 SER A 409
LEU A 226
ASP A 254
GLY A 239
ALA A 256
 None
 1.34A 2kceA-2gbxA:
undetectable		 2kceA-2gbxA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 8 GLY A 148
ILE A 313
ASN A 301
ALA A  75
 None
 0.86A 2x0pA-2gbxA:
undetectable		 2x0pA-2gbxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		3 / 3 SER A  66
ARG A  74
GLN A  68
 None
 0.89A 2xnrA-2gbxA:
undetectable		 2xnrA-2gbxA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 5 PHE A 201
ILE A 313
ASN A 363
PHE A 311
 BNL  A 457 ( 4.2A)
None
None
None
 1.36A 3octA-2gbxA:
undetectable		 3octA-2gbxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 8 GLY A 401
TYR A 396
PRO A 394
ARG A 288
 None
 0.93A 3s3nA-2gbxA:
undetectable		 3s3nA-2gbxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 6 GLU A 163
GLY A 398
PHE A 440
ARG A 443
 None
 1.40A 5jcnB-2gbxA:
undetectable		 5jcnB-2gbxA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		4 / 5 ASP A 422
ILE A  33
PHE A 299
ASN A  12
 None
 1.13A 6a93B-2gbxA:
undetectable		 6a93B-2gbxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT
(Sphingobium
yanoikuyae) 		3 / 3 ARG A 165
GLY A 162
GLU A 163
 None
 0.61A 6fgdA-2gbxA:
undetectable		 6fgdA-2gbxA:
22.11