SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 8 SER A 227
ALA A 266
PHE A 240
GLU A 243
 None
 1.12A 1dmiA-2gcaA:
undetectable
1dmiB-2gcaA:
undetectable		 1dmiA-2gcaA:
21.97
1dmiB-2gcaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		3 / 3 ALA A 104
VAL A 102
TRP A 130
 None
 0.83A 1nt6A-2gcaA:
undetectable		 1nt6A-2gcaA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		3 / 3 ALA A 104
VAL A 102
TRP A 130
 None
 0.82A 1nt6B-2gcaA:
undetectable		 1nt6B-2gcaA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		3 / 3 ASP A 306
LEU A 309
HIS A 234
 None
 0.64A 1qknA-2gcaA:
undetectable		 1qknA-2gcaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.92A 1ra8A-2gcaA:
2.7		 1ra8A-2gcaA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.91A 1rd7B-2gcaA:
2.6		 1rd7B-2gcaA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		3 / 3 ARG A  78
VAL A  99
THR A   6
 None
 0.71A 3cyxA-2gcaA:
undetectable		 3cyxA-2gcaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 10 THR A 422
VAL A 419
ILE A 312
ILE A 304
SER A 305
 None
 1.32A 3kpbD-2gcaA:
undetectable		 3kpbD-2gcaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 8 VAL A 139
VAL A 162
TYR A 275
ILE A  57
 None
 1.05A 3remB-2gcaA:
undetectable		 3remB-2gcaA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 11 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.87A 4j6cA-2gcaA:
undetectable		 4j6cA-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 10 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.87A 4j6cB-2gcaA:
undetectable		 4j6cB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.89A 4j6dA-2gcaA:
undetectable		 4j6dA-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.90A 4j6dB-2gcaA:
undetectable		 4j6dB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.87A 4jbtA-2gcaA:
undetectable		 4jbtA-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 11 ALA A 206
ALA A 210
ALA A 209
VAL A 195
LEU A 163
 None
 0.88A 4jbtB-2gcaA:
undetectable		 4jbtB-2gcaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 415
LEU A 395
THR A 337
ILE A 312
ILE A 310
 None
 1.06A 4o2bB-2gcaA:
3.1		 4o2bB-2gcaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLY A  49
ALA A  53
PHE A 222
ALA A 266
VAL A 228
 None
 1.12A 4ryaA-2gcaA:
undetectable		 4ryaA-2gcaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.92A 4x5fA-2gcaA:
4.3		 4x5fA-2gcaA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.86A 4x5fB-2gcaA:
4.4		 4x5fB-2gcaA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.95A 4x5gB-2gcaA:
2.8		 4x5gB-2gcaA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A 288
LEU A  61
ALA A 268
ILE A 269
 None
 0.74A 4y03A-2gcaA:
undetectable		 4y03A-2gcaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 5 GLU A 165
THR A 164
HIS A 296
LEU A 256
 None
 1.13A 5axaA-2gcaA:
2.4		 5axaA-2gcaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 5 GLU A 165
THR A 164
HIS A 296
LEU A 256
 None
 1.15A 5axaC-2gcaA:
2.4		 5axaC-2gcaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 5 ALA A  93
TYR A   3
PRO A  89
GLY A  51
 None
 0.99A 5eslA-2gcaA:
undetectable		 5eslA-2gcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 415
LEU A 395
THR A 337
ILE A 312
ILE A 310
 None
 1.02A 5mioB-2gcaA:
2.4		 5mioB-2gcaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 5 HIS A  59
MET A  84
VAL A  68
LEU A  70
 None
 1.30A 5xdhD-2gcaA:
0.0		 5xdhD-2gcaA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A 188
THR A 271
ILE A 267
ARG A 263
THR A 153
 None
 0.98A 5z6fA-2gcaA:
undetectable		 5z6fA-2gcaA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2gca FOLYLPOLYGLUTAMATE
SYNTHASE
(Lactobacillus
casei) 		4 / 7 THR A  45
LEU A 163
ILE A 267
THR A 197
 None
 1.04A 5zsfA-2gcaA:
undetectable
5zsfB-2gcaA:
undetectable		 5zsfA-2gcaA:
11.57
5zsfB-2gcaA:
11.57