SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 7 TYR A  29
PHE A 150
ILE A 157
GLY A 152
 None
None
EDO  A2003 (-4.9A)
None
 0.93A 11gsA-2gcuA:
undetectable		 11gsA-2gcuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 12 ALA A 103
ASP A 104
GLY A  82
VAL A  73
ILE A  95
 None
 0.92A 1sdtB-2gcuA:
undetectable		 1sdtB-2gcuA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 12 HIS A  72
ILE A  95
LEU A  43
ASP A  54
VAL A  51
 FE2  A 300 (-3.3A)
None
None
None
None
 1.25A 1zq9A-2gcuA:
undetectable		 1zq9A-2gcuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 12 ALA A 103
ASP A 104
GLY A  82
VAL A  73
ILE A  95
 None
 0.86A 2avoB-2gcuA:
undetectable		 2avoB-2gcuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 8 HIS A  72
HIS A  74
ASP A 153
HIS A 194
GLY A 152
 FE2  A 300 (-3.3A)
None
FE2  A 300 (-3.1A)
None
None
 1.40A 3c0zB-2gcuA:
undetectable		 3c0zB-2gcuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 6 ASP A 164
HIS A  72
HIS A 128
ASP A  76
 None
FE2  A 300 (-3.3A)
FE2  A 300 (-3.4A)
None
 0.87A 3c0zC-2gcuA:
undetectable		 3c0zC-2gcuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 7 TYR A  29
PHE A 150
ILE A 157
GLY A 152
 None
None
EDO  A2003 (-4.9A)
None
 1.00A 3gssA-2gcuA:
undetectable		 3gssA-2gcuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 7 TYR A  29
PHE A 150
ILE A 157
GLY A 152
 None
None
EDO  A2003 (-4.9A)
None
 1.00A 3gssB-2gcuA:
undetectable		 3gssB-2gcuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 8 TYR A  29
PHE A 150
ILE A 157
GLY A 152
 None
None
EDO  A2003 (-4.9A)
None
 0.95A 3n9jA-2gcuA:
undetectable		 3n9jA-2gcuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 12 HIS A 128
GLY A 152
HIS A  74
ASP A  76
HIS A  77
 FE2  A 300 (-3.4A)
None
None
None
None
 1.28A 4bz6C-2gcuA:
undetectable		 4bz6C-2gcuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 8 THR A 129
LEU A 156
GLY A 152
THR A  71
 None
EDO  A2009 ( 4.0A)
None
None
 0.85A 4c9nA-2gcuA:
undetectable		 4c9nA-2gcuA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 8 ILE A  58
LEU A  30
ILE A  66
LYS A  12
 None
 0.89A 4hb6A-2gcuA:
undetectable		 4hb6A-2gcuA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 11 HIS A  72
HIS A  74
ASP A 153
HIS A 194
GLY A 152
 FE2  A 300 (-3.3A)
None
FE2  A 300 (-3.1A)
None
None
 1.42A 4lxzB-2gcuA:
undetectable		 4lxzB-2gcuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 11 THR A 203
SER A 202
ASP A 195
PHE A 199
GLU A 206
 None
EDO  A2003 ( 4.4A)
EDO  A2009 ( 3.6A)
EDO  A2003 (-3.8A)
EDO  A2003 (-2.8A)
 1.29A 4xt7A-2gcuA:
undetectable		 4xt7A-2gcuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 ARG A 162
ASP A 164
TYR A 232
 SO4  A3001 (-3.9A)
None
None
 0.87A 4yo9B-2gcuA:
undetectable		 4yo9B-2gcuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 5 GLU A 121
THR A 137
THR A  71
HIS A 128
 None
None
None
FE2  A 300 (-3.4A)
 1.23A 5axaA-2gcuA:
undetectable		 5axaA-2gcuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 5 GLU A 121
THR A 137
THR A  71
HIS A 128
 None
None
None
FE2  A 300 (-3.4A)
 1.19A 5axaC-2gcuA:
undetectable		 5axaC-2gcuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		5 / 12 ASN A 243
HIS A  74
ASP A  45
LEU A  42
ILE A  44
 None
 1.27A 5dv4A-2gcuA:
undetectable		 5dv4A-2gcuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 8 LEU A 107
VAL A 122
MET A  69
TYR A  67
 None
 1.03A 5nu7A-2gcuA:
undetectable		 5nu7A-2gcuA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 HIS A 194
ASP A  76
HIS A  77
 None
 0.80A 5oexA-2gcuA:
undetectable		 5oexA-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 HIS A 128
HIS A  72
HIS A  74
 FE2  A 300 (-3.4A)
FE2  A 300 (-3.3A)
None
 1.02A 5oexA-2gcuA:
undetectable		 5oexA-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 HIS A 194
ASP A  76
HIS A  77
 None
 0.78A 5oexB-2gcuA:
undetectable		 5oexB-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 HIS A 194
ASP A  76
HIS A  77
 None
 0.76A 5oexC-2gcuA:
undetectable		 5oexC-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 HIS A 194
ASP A  76
HIS A  77
 None
 0.73A 5oexD-2gcuA:
undetectable		 5oexD-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		4 / 6 ARG A  53
THR A  28
ASP A  45
LEU A  43
 None
 1.19A 5tdzA-2gcuA:
undetectable		 5tdzA-2gcuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3
(Arabidopsis
thaliana) 		3 / 3 LEU A 228
ASN A 211
LEU A 173
 None
 0.59A 6exiD-2gcuA:
undetectable		 6exiD-2gcuA:
17.80