SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  94
LEU A  61
ALA A  70
LEU A  73
ILE A 168
 None
CAA  A1751 (-3.9A)
None
None
None
 1.16A 1crbA-2gd2A:
undetectable		 1crbA-2gd2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 224
PRO A 222
LEU A 275
THR A 299
 None
 1.11A 1i2wA-2gd2A:
undetectable		 1i2wA-2gd2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  35
ALA A  31
VAL A  79
ILE A  25
VAL A  10
 None
 0.97A 2nnpB-2gd2A:
undetectable		 2nnpB-2gd2A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		3 / 3 ILE A  74
ILE A  36
LEU A 172
 None
 0.41A 2prgA-2gd2A:
undetectable		 2prgA-2gd2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  73
GLY A  66
ALA A  59
ASP A  60
VAL A  11
ILE A  36
 None
None
None
CAA  A1751 ( 4.7A)
None
None
 1.39A 2q63A-2gd2A:
undetectable		 2q63A-2gd2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 168
ILE A  36
ILE A  74
LEU A 106
CYH A  99
 None
 1.08A 2qo5A-2gd2A:
undetectable		 2qo5A-2gd2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 8 LEU A  61
ILE A  36
LEU A  13
THR A  89
LEU A  92
 CAA  A1751 (-3.9A)
None
None
None
CAA  A1751 (-4.2A)
 1.22A 2xfhA-2gd2A:
undetectable		 2xfhA-2gd2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 8 LEU A  61
ILE A  36
LEU A  13
THR A  89
LEU A  94
 CAA  A1751 (-3.9A)
None
None
None
None
 1.44A 2xfhA-2gd2A:
undetectable		 2xfhA-2gd2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 196
GLY A 191
GLY A 159
ALA A 186
ASP A 185
 None
 1.15A 2yvlD-2gd2A:
3.6		 2yvlD-2gd2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 7 GLU A  90
ARG A  91
ARG A 110
GLU A  82
 None
CAA  A1751 (-2.2A)
None
None
 0.99A 2zt7A-2gd2A:
undetectable		 2zt7A-2gd2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 131
PRO A 147
LEU A 137
ASP A 127
 None
 1.20A 3oi8A-2gd2A:
undetectable		 3oi8A-2gd2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  51
ARG A  35
PRO A  20
ALA A  23
 None
 1.49A 3vm4A-2gd2A:
undetectable		 3vm4A-2gd2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  57
ILE A  36
ARG A  35
LEU A  13
ILE A 351
 None
 1.08A 4kukA-2gd2A:
undetectable		 4kukA-2gd2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
ALA A 109
ILE A  25
GLY A  19
VAL A  33
 None
 1.08A 4nkxD-2gd2A:
undetectable		 4nkxD-2gd2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  35
GLY A  15
GLY A  19
PRO A  20
 None
 0.68A 4u9uA-2gd2A:
2.3		 4u9uA-2gd2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  35
GLY A  15
GLY A  19
PRO A  20
 None
 0.80A 4u9uB-2gd2A:
2.3		 4u9uB-2gd2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
GLY A 213
GLY A 143
LEU A 217
ALA A 221
 None
 0.93A 4uciA-2gd2A:
2.0		 4uciA-2gd2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
GLY A 213
GLY A 143
LEU A 217
ALA A 221
 None
 0.93A 4uciB-2gd2A:
undetectable		 4uciB-2gd2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
GLY A 213
GLY A 143
LEU A 217
ALA A 221
 None
 0.95A 4uckA-2gd2A:
undetectable		 4uckA-2gd2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 271
LEU A 275
LEU A 259
ALA A 246
LEU A 249
 None
 1.01A 4wg0H-2gd2A:
undetectable
4wg0I-2gd2A:
undetectable
4wg0J-2gd2A:
undetectable		 4wg0H-2gd2A:
3.06
4wg0I-2gd2A:
3.06
4wg0J-2gd2A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  23
LEU A  26
LEU A   8
LEU A 172
LEU A 169
 None
 1.22A 4wg0I-2gd2A:
undetectable
4wg0J-2gd2A:
undetectable
4wg0K-2gd2A:
undetectable		 4wg0I-2gd2A:
3.06
4wg0J-2gd2A:
3.06
4wg0K-2gd2A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 246
LEU A 249
LEU A 259
LEU A 271
LEU A 275
 None
 1.00A 4wg0I-2gd2A:
undetectable
4wg0J-2gd2A:
undetectable
4wg0K-2gd2A:
undetectable		 4wg0I-2gd2A:
3.06
4wg0J-2gd2A:
3.06
4wg0K-2gd2A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  70
ILE A  36
GLY A  93
LEU A  92
ASP A  60
 None
None
None
CAA  A1751 (-4.2A)
CAA  A1751 ( 4.7A)
 1.43A 5ajqB-2gd2A:
undetectable		 5ajqB-2gd2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 275
LEU A 252
ARG A 233
 None
 0.39A 5hnzB-2gd2A:
undetectable		 5hnzB-2gd2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  79
ILE A  81
VAL A 184
ALA A 109
 None
 0.76A 5ospA-2gd2A:
undetectable		 5ospA-2gd2A:
21.59