SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		4 / 6 VAL A 173
MET A 162
ARG A 158
THR A 153
 None
None
ANP  A 401 (-3.7A)
MG  A 501 ( 4.0A)
 1.24A 2x2iA-2gdjA:
undetectable		 2x2iA-2gdjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		4 / 6 HIS A 280
THR A 214
PHE A 217
GLN A 188
 None
 1.16A 3bgdA-2gdjA:
undetectable		 3bgdA-2gdjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		3 / 3 THR A 283
SER A  99
PHE A 103
 None
MG  A 502 ( 4.7A)
None
 0.68A 3d4sA-2gdjA:
undetectable		 3d4sA-2gdjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		3 / 3 GLY A 108
GLY A 110
THR A 112
 ANP  A 401 (-3.2A)
ANP  A 401 (-3.4A)
MG  A 501 ( 3.3A)
 0.43A 3si7B-2gdjA:
6.7		 3si7B-2gdjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		5 / 12 ARG A  74
GLY A  94
GLY A  93
GLY A  92
LEU A  87
 None
 1.01A 4htfB-2gdjA:
undetectable		 4htfB-2gdjA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		5 / 12 LEU A  91
PHE A 313
SER A 118
ILE A 320
GLU A  86
 None
 1.40A 5w8aA-2gdjA:
undetectable		 5w8aA-2gdjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Methanococcus
voltae) 		4 / 5 GLN A 123
VAL A 120
PRO A 143
THR A  82
 None
 1.20A 6cduI-2gdjA:
undetectable
6cduJ-2gdjA:
0.0		 6cduI-2gdjA:
20.59
6cduJ-2gdjA:
20.59