SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 SER A  89
PHE A  59
LYS A  61
 None
 0.84A 3u88A-2gdtA:
undetectable		 3u88A-2gdtA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 LEU A  53
LEU A  96
THR A  92
GLN A  85
 None
 1.20A 5hbsA-2gdtA:
undetectable		 5hbsA-2gdtA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 LEU A  77
CYH A  40
HIS A  34
LEU A  96
 None
 1.11A 5hpuC-2gdtA:
undetectable
5hpuD-2gdtA:
undetectable		 5hpuC-2gdtA:
10.09
5hpuD-2gdtA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 GLU A  25
ALA A  31
LEU A  96
TYR A  86
 None
 1.06A 5igiA-2gdtA:
undetectable		 5igiA-2gdtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1 (EC 3.4.22.-)
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 LEU A  28
LEU A  77
VAL A  95
LEU A  96
ALA A  31
 None
 1.06A 5o96G-2gdtA:
undetectable
5o96H-2gdtA:
undetectable		 5o96G-2gdtA:
23.05
5o96H-2gdtA:
23.05