SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
None
NAD  A 300 (-3.3A)
None
None
 1.04A 1eqhB-2gdzA:
undetectable		 1eqhB-2gdzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		7 / 11 GLY A  12
ALA A  14
ASP A  36
ASP A  64
VAL A  65
ALA A  92
VAL A  94
 NAD  A 300 (-3.3A)
NAD  A 300 ( 3.9A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.5A)
NAD  A 300 (-3.6A)
None
 0.29A 1uayA-2gdzA:
27.8		 1uayA-2gdzA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		7 / 10 GLY A  12
ALA A  14
ASP A  36
ASP A  64
VAL A  65
ALA A  92
VAL A  94
 NAD  A 300 (-3.3A)
NAD  A 300 ( 3.9A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.5A)
NAD  A 300 (-3.6A)
None
 0.27A 1uayB-2gdzA:
27.6		 1uayB-2gdzA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A  12
ASP A  36
ASP A  64
ASN A  91
ALA A  92
 NAD  A 300 (-3.3A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.2A)
NAD  A 300 (-3.6A)
 0.96A 2bm9E-2gdzA:
6.1		 2bm9E-2gdzA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 10 ASP A  36
ASN A  38
ALA A  14
ASP A  64
VAL A  65
 NAD  A 300 (-2.8A)
None
NAD  A 300 ( 3.9A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.5A)
 1.02A 3ay0A-2gdzA:
7.2		 3ay0A-2gdzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		3 / 3 LYS A  28
LYS A   0
VAL A   3
 None
 1.05A 3brfA-2gdzA:
undetectable		 3brfA-2gdzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
None
NAD  A 300 (-3.3A)
None
None
 1.05A 3n8zA-2gdzA:
undetectable		 3n8zA-2gdzA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 11 ALA A  14
ASP A  36
THR A 188
ILE A 190
ILE A  17
 NAD  A 300 ( 3.9A)
NAD  A 300 (-2.8A)
NAD  A 300 (-2.7A)
NAD  A 300 (-3.9A)
NAD  A 300 (-3.9A)
 1.12A 3tqbA-2gdzA:
undetectable		 3tqbA-2gdzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		4 / 7 SER A 138
GLN A 148
TYR A 151
LEU A 191
 NAD  A 300 (-3.5A)
None
NAD  A 300 (-4.5A)
NAD  A 300 ( 4.4A)
 0.90A 4hxyB-2gdzA:
18.6		 4hxyB-2gdzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		3 / 3 LEU A 117
ASP A 120
TYR A 121
 None
 0.61A 4qc6B-2gdzA:
undetectable		 4qc6B-2gdzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 123
THR A 162
ALA A 166
ALA A 168
ASN A 239
 None
 0.98A 4u14A-2gdzA:
undetectable		 4u14A-2gdzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 123
THR A 162
ALA A 166
ALA A 168
ASN A 239
 None
 1.25A 4u15A-2gdzA:
undetectable		 4u15A-2gdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 123
THR A 162
ALA A 166
ALA A 168
ASN A 239
 None
 1.03A 4u15B-2gdzA:
undetectable		 4u15B-2gdzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		4 / 5 ILE A 219
GLY A 184
ILE A 214
LEU A 220
 None
 0.90A 5dzkd-2gdzA:
undetectable
5dzkk-2gdzA:
undetectable
5dzky-2gdzA:
undetectable		 5dzkd-2gdzA:
24.03
5dzkk-2gdzA:
21.07
5dzky-2gdzA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		4 / 4 ILE A 219
GLY A 184
ILE A 214
LEU A 220
 None
 0.86A 5dzkl-2gdzA:
undetectable
5dzkz-2gdzA:
undetectable		 5dzkl-2gdzA:
21.07
5dzkz-2gdzA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		5 / 8 VAL A  78
VAL A   3
ILE A 132
ILE A 230
ILE A 134
 None
 1.25A 5hi2A-2gdzA:
undetectable		 5hi2A-2gdzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		4 / 5 GLY A  42
ASN A  38
ASP A  36
ARG A  19
 None
None
NAD  A 300 (-2.8A)
None
 1.25A 6dwdB-2gdzA:
undetectable
6dwdD-2gdzA:
undetectable		 6dwdB-2gdzA:
21.84
6dwdD-2gdzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens) 		4 / 5 ARG A  19
GLY A  42
ASN A  38
ASP A  36
 None
None
None
NAD  A 300 (-2.8A)
 1.23A 6dwjB-2gdzA:
undetectable
6dwjD-2gdzA:
undetectable		 6dwjB-2gdzA:
21.84
6dwjD-2gdzA:
21.84