SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ge5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_D_H4BD3902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	2ge5	TYPE II RESTRICTION ENZYME ECORV (Escherichia coli)	4 / 8	TRP A 174 GLU A 209 ARG A 4 ILE A 129	None	1.43A	3e7gC-2ge5A: undetectable 3e7gD-2ge5A: undetectable	3e7gC-2ge5A: 18.89 3e7gD-2ge5A: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G10_A_ACTA301_0 (GLUTATHIONE S-TRANSFERASE HOMOLOG)	2ge5	TYPE II RESTRICTION ENZYME ECORV (Escherichia coli)	4 / 6	ILE A 205 TYR A 219 TYR A 215 PHE A 206	None	1.22A	4g10A-2ge5A: undetectable	4g10A-2ge5A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI507_0 (RNA POLYMERASE 3D-POL)	2ge5	TYPE II RESTRICTION ENZYME ECORV (Escherichia coli)	3 / 3	LYS A 79 PRO A 80 SER A 81	None	0.46A	4k50I-2ge5A: undetectable	4k50I-2ge5A: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_A_8NUA3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	2ge5	TYPE II RESTRICTION ENZYME ECORV (Escherichia coli)	5 / 12	THR A 96 ILE A 103 LEU A 33 PHE A 105 PHE A 44	None	1.30A	6a93A-2ge5A: undetectable	6a93A-2ge5A: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EKU_A_ZMRA901_2 (SIALIDASE)	2ge5	TYPE II RESTRICTION ENZYME ECORV (Escherichia coli)	4 / 6	ASP A 90 ASN A 188 SER A 112 PHE A 125	CA A 283 (-2.9A) None None None	1.20A	6ekuA-2ge5A: undetectable	6ekuA-2ge5A: 14.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3E7G_D_H4BD3902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","2ge5","TYPE II RESTRICTION ENZYME ECORV","Escherichia coli",4,"TRP A 174;GLU A 209;ARG A   4;ILE A 129","None","1.43A","3e7gC-2ge5A:undetectable;3e7gD-2ge5A:undetectable","3e7gC-2ge5A:18.89;3e7gD-2ge5A:18.89"],["4G10_A_ACTA301_0","GLUTATHIONE S-TRANSFERASE HOMOLOG","2ge5","TYPE II RESTRICTION ENZYME ECORV","Escherichia coli",4,"ILE A 205;TYR A 219;TYR A 215;PHE A 206","None","1.22A","4g10A-2ge5A:undetectable","4g10A-2ge5A:19.23"],["4K50_I_ACTI507_0","RNA POLYMERASE 3D-POL","2ge5","TYPE II RESTRICTION ENZYME ECORV","Escherichia coli",3,"LYS A  79;PRO A  80;SER A  81","None","0.46A","4k50I-2ge5A:undetectable","4k50I-2ge5A:18.71"],["6A93_A_8NUA3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","2ge5","TYPE II RESTRICTION ENZYME ECORV","Escherichia coli",5,"THR A  96;ILE A 103;LEU A  33;PHE A 105;PHE A  44","None","1.30A","6a93A-2ge5A:undetectable","6a93A-2ge5A:19.84"],["6EKU_A_ZMRA901_2","SIALIDASE","2ge5","TYPE II RESTRICTION ENZYME ECORV","Escherichia coli",4,"ASP A  90;ASN A 188;SER A 112;PHE A 125"," CA A 283 (-2.9A);None;None;None","1.20A","6ekuA-2ge5A:undetectable","6ekuA-2ge5A:14.62"]]