SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2geb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		6 / 12 ILE A  99
LEU A  62
ASP A  32
LEU A  54
LEU A  25
VAL A  22
 None
 1.50A 2yqzB-2gebA:
3.9		 2yqzB-2gebA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		4 / 4 ASP A 161
GLY A  46
ASP A 102
ASP A 105
 None
None
CA  A 201 (-2.9A)
None
 0.97A 5e72A-2gebA:
undetectable		 5e72A-2gebA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A  81
THR A  76
GLU A 138
SER A 106
 None
 0.99A 6c06C-2gebA:
undetectable		 6c06C-2gebA:
undetectable