SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ged'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 114
LEU A 132
VAL A 221
ALA A 219
LEU A 217
 None
 1.17A 1e7bA-2gedA:
undetectable		 1e7bA-2gedA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 THR A  52
GLY A  50
ARG A 237
ILE A 228
 SO4  A 401 (-3.8A)
SO4  A 401 (-3.3A)
None
None
 0.92A 4ac9C-2gedA:
4.8		 4ac9C-2gedA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 THR A  52
GLY A  50
ARG A 237
ILE A 228
 SO4  A 401 (-3.8A)
SO4  A 401 (-3.3A)
None
None
 0.92A 4acbC-2gedA:
5.0		 4acbC-2gedA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 231
LYS A 232
LYS A 230
 None
 1.29A 4k50A-2gedA:
undetectable		 4k50A-2gedA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 231
LYS A 232
LYS A 230
 None
 1.35A 4k50E-2gedA:
undetectable		 4k50E-2gedA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2ged SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 231
LYS A 232
LYS A 230
 None
 1.31A 4k50I-2gedA:
undetectable		 4k50I-2gedA:
18.14