SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.66A 1grmA-2genA:
undetectable		 1grmA-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.67A 1grmB-2genA:
undetectable		 1grmB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.79A 1jnoA-2genA:
undetectable		 1jnoA-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.79A 1jnoB-2genA:
undetectable		 1jnoB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.82A 1jo3A-2genA:
undetectable		 1jo3A-2genA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.82A 1jo3B-2genA:
undetectable		 1jo3B-2genA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.62A 1jo4A-2genA:
undetectable		 1jo4A-2genA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.62A 1jo4B-2genA:
undetectable		 1jo4B-2genA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.67A 1magA-2genA:
undetectable		 1magA-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.67A 1magB-2genA:
undetectable		 1magB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.74A 1ng8A-2genA:
undetectable		 1ng8A-2genA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.74A 1ng8B-2genA:
undetectable		 1ng8B-2genA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.66A 1nrmA-2genA:
undetectable		 1nrmA-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.66A 1nrmB-2genA:
undetectable		 1nrmB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.69A 1nruA-2genA:
undetectable		 1nruA-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.69A 1nruB-2genA:
undetectable		 1nruB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.82A 1nt5A-2genA:
undetectable		 1nt5A-2genA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 192
VAL A 190
TRP A 187
 None
 0.83A 1nt5B-2genA:
undetectable		 1nt5B-2genA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 109
THR A  26
VAL A  23
 None
 0.77A 2q64A-2genA:
undetectable		 2q64A-2genA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 109
THR A  26
VAL A  23
 None
 0.95A 2qakA-2genA:
undetectable		 2qakA-2genA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 112
LEU A 115
GLY A  54
THR A  26
 None
 0.86A 3dl9A-2genA:
undetectable		 3dl9A-2genA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 PRO A  97
THR A  26
VAL A  23
GLY A  22
 None
 1.08A 3elzA-2genA:
undetectable		 3elzA-2genA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 122
LEU A 119
ILE A 103
PHE A 102
 None
 1.21A 3s3vA-2genA:
undetectable		 3s3vA-2genA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  59
ILE A  61
ARG A 118
HIS A 126
 None
 0.96A 3v4tH-2genA:
undetectable		 3v4tH-2genA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 101
THR A 171
TRP A 166
 None
 1.21A 4uglA-2genA:
2.0		 4uglA-2genA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 191
ASP A 188
TRP A 187
 None
 0.91A 4xdqA-2genA:
undetectable		 4xdqA-2genA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  64
LEU A  68
ILE A 156
PHE A 151
VAL A 190
 None
 1.21A 6djzB-2genA:
undetectable		 6djzB-2genA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  22
PHE A  18
HIS A  21
LYS A  49
 None
 0.97A 6hu9S-2genA:
undetectable
6hu9q-2genA:
undetectable		 6hu9S-2genA:
18.46
6hu9q-2genA:
19.10