SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 PHE A 122
GLY A 110
LEU A 380
MET A 136
ALA A  98
None
1.37A 1e3vA-2gepA:
0.0
1e3vA-2gepA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 PHE A 122
GLY A 110
LEU A 380
MET A 136
ALA A  98
None
1.37A 1e3vB-2gepA:
0.0
1e3vB-2gepA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
6 / 11 ASP A 227
ALA A 394
GLY A  89
THR A 219
VAL A 221
ILE A 228
None
1.32A 1ohrA-2gepA:
undetectable
1ohrA-2gepA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 ASP A 550
GLY A 506
ARG A 513
ILE A 514
ALA A 232
None
None
None
None
SRM  A 580 (-4.2A)
1.15A 1oltA-2gepA:
undetectable
1oltA-2gepA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 THR A  92
LEU A 137
VAL A 140
GLY A 141
ILE A  91
None
1.18A 1phgA-2gepA:
undetectable
1phgA-2gepA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 ILE A 458
PHE A 450
LEU A 451
ILE A 527
None
0.95A 1yc2E-2gepA:
undetectable
1yc2E-2gepA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 VAL A 289
PHE A 274
THR A 219
LEU A 230
LEU A 311
None
1.24A 2jn3A-2gepA:
undetectable
2jn3A-2gepA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 6 THR A 512
ARG A 513
ASN A 395
ASP A 344
None
1.34A 2okcA-2gepA:
undetectable
2okcA-2gepA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 ALA A 103
GLY A 110
GLY A 124
LEU A 380
ASN A 106
None
1.06A 2y7hB-2gepA:
undetectable
2y7hB-2gepA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 ALA A 103
GLY A 110
GLY A 124
LEU A 380
ASN A 106
None
1.06A 2y7hC-2gepA:
undetectable
2y7hC-2gepA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 SER A 530
MET A 474
PHE A 548
ILE A 472
PHE A 454
None
1.27A 3aocC-2gepA:
undetectable
3aocC-2gepA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
6 / 11 ASP A 227
ALA A 394
ASN A 116
GLY A  89
VAL A 221
ILE A 228
None
None
SRM  A 580 (-3.5A)
None
None
None
1.38A 3lzvB-2gepA:
undetectable
3lzvB-2gepA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 5 PHE A 274
ILE A 329
MET A 235
ASN A 233
None
1.35A 3octA-2gepA:
undetectable
3octA-2gepA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
6 / 11 ASP A 227
ALA A 394
GLY A  89
VAL A  90
VAL A 220
ILE A 228
None
1.27A 3oxvD-2gepA:
undetectable
3oxvD-2gepA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
3 / 3 THR A 147
ASP A 143
GLU A 179
None
0.73A 3qowA-2gepA:
undetectable
3qowA-2gepA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 8 ASP A 227
ALA A 394
GLY A  89
VAL A 221
ILE A 228
None
1.35A 4ll3A-2gepA:
undetectable
4ll3A-2gepA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 8 VAL A 491
LEU A 505
LEU A 503
ASP A 532
ILE A 535
None
1.34A 4lzrA-2gepA:
undetectable
4lzrA-2gepA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 8 ALA A 241
GLY A 248
LEU A 246
LEU A 166
None
0.88A 4po0A-2gepA:
undetectable
4po0A-2gepA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 GLY A 484
GLY A 482
ASN A 481
ALA A 394
THR A 393
None
SF4  A 575 (-4.2A)
SRM  A 580 ( 3.5A)
None
None
1.01A 4uckB-2gepA:
undetectable
4uckB-2gepA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 ALA A 383
ILE A  91
LEU A 398
PHE A 390
None
0.98A 4uymB-2gepA:
undetectable
4uymB-2gepA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 8 ALA A 555
ILE A 557
GLU A 541
ALA A 539
LEU A 534
None
1.31A 4v1fA-2gepA:
undetectable
4v1fB-2gepA:
undetectable
4v1fA-2gepA:
10.41
4v1fB-2gepA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
None
1.05A 4x1kD-2gepA:
2.0
4x1kD-2gepA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 12 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
None
1.08A 4x1yD-2gepA:
undetectable
4x1yD-2gepA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
None
0.80A 5a06A-2gepA:
undetectable
5a06A-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
None
0.80A 5a06B-2gepA:
undetectable
5a06B-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
None
0.80A 5a06C-2gepA:
undetectable
5a06C-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
None
0.79A 5a06E-2gepA:
undetectable
5a06E-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
None
0.80A 5a06F-2gepA:
undetectable
5a06F-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 7 ALA A 305
GLY A 208
THR A 185
GLU A 204
None
0.97A 5bs8A-2gepA:
2.3
5bs8B-2gepA:
undetectable
5bs8C-2gepA:
3.2
5bs8A-2gepA:
24.60
5bs8B-2gepA:
18.89
5bs8C-2gepA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
3 / 3 PHE A 548
ILE A 535
ASP A 469
None
0.69A 5cswB-2gepA:
2.6
5cswB-2gepA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 4 VAL A 253
GLY A 254
ARG A 269
VAL A 316
None
1.42A 5d4nA-2gepA:
1.3
5d4nB-2gepA:
1.0
5d4nA-2gepA:
14.01
5d4nB-2gepA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
3 / 3 LYS A 376
LEU A 360
ILE A 414
None
0.65A 5kc0A-2gepA:
undetectable
5kc0A-2gepA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 10 LEU A 398
ALA A 103
PHE A 122
THR A 119
LEU A 137
None
None
None
SRM  A 580 (-4.2A)
None
1.09A 5mm4B-2gepA:
undetectable
5mm4B-2gepA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 7 GLY A 262
LEU A 503
ILE A 259
LEU A 568
ILE A 558
None
1.28A 5vkqA-2gepA:
undetectable
5vkqB-2gepA:
undetectable
5vkqA-2gepA:
13.85
5vkqB-2gepA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 8 PHE A 122
ILE A 125
PHE A 102
PRO A 132
None
1.07A 5x23A-2gepA:
undetectable
5x23A-2gepA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
4 / 8 ILE A 177
VAL A 220
ALA A 239
TYR A 337
None
0.89A 6cduD-2gepA:
undetectable
6cduE-2gepA:
undetectable
6cduD-2gepA:
20.80
6cduE-2gepA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
3 / 3 GLY A 536
ASP A 532
ILE A 458
None
0.55A 6dgxB-2gepA:
undetectable
6dgxB-2gepA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
None
1.02A 6ebzA-2gepA:
undetectable
6ebzA-2gepA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
None
1.03A 6ebzB-2gepA:
undetectable
6ebzB-2gepA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
None
1.05A 6ebzC-2gepA:
undetectable
6ebzC-2gepA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
None
1.04A 6ebzD-2gepA:
undetectable
6ebzD-2gepA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
5 / 10 GLY A 549
GLY A 547
VAL A 491
THR A 552
ILE A 558
None
1.03A 6exiB-2gepA:
undetectable
6exiB-2gepA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli)
3 / 3 ARG A 509
GLY A 547
GLU A 546
None
0.60A 6fgdA-2gepA:
1.5
6fgdA-2gepA:
22.49