SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ger'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 GLN A  10
GLY A   4
SER A  33
LEU A  66
ALA A  69
 None
 1.26A 3d91B-2gerA:
undetectable		 3d91B-2gerA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 8 GLY A   7
ALA A   8
ASP A  38
LEU A  15
VAL A  50
 None
 1.42A 3em6A-2gerA:
undetectable		 3em6A-2gerA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 9 VAL A  70
ALA A  12
THR A  59
SER A  63
ILE A   6
 None
 1.50A 3hbbB-2gerA:
undetectable		 3hbbB-2gerA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 SER A  63
ALA A  12
PHE A  19
THR A  20
LEU A 153
 None
 1.47A 4z7fC-2gerA:
undetectable		 4z7fC-2gerA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LYS A  57
LEU A  68
ILE A  86
 None
 0.75A 5kc4A-2gerA:
undetectable		 5kc4A-2gerA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 PHE A 182
ASP A 186
LEU A 253
 None
 0.75A 5uhcC-2gerA:
undetectable		 5uhcC-2gerA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.72A 6baaE-2gerA:
undetectable		 6baaE-2gerA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.72A 6baaF-2gerA:
undetectable		 6baaF-2gerA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.73A 6baaG-2gerA:
undetectable		 6baaG-2gerA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.73A 6baaH-2gerA:
undetectable		 6baaH-2gerA:
11.50