SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 6 LEU A 160
ILE A 104
TRP A 142
VAL A  10
 None
 1.03A 1db1A-2gf0A:
undetectable		 1db1A-2gf0A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 7 LEU A 160
LEU A 164
PHE A 161
LEU A  23
 None
 0.98A 2vq5B-2gf0A:
undetectable		 2vq5B-2gf0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 6 ILE A  76
TYR A 101
ILE A 114
HIS A  80
 None
 0.97A 3eteA-2gf0A:
undetectable
3eteE-2gf0A:
undetectable		 3eteA-2gf0A:
16.97
3eteE-2gf0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 5 ILE A  76
TYR A 101
ILE A 114
HIS A  80
 None
 0.95A 3eteB-2gf0A:
undetectable
3eteC-2gf0A:
undetectable		 3eteB-2gf0A:
16.97
3eteC-2gf0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 7 ILE A 114
HIS A  80
ILE A  76
TYR A 101
 None
 0.97A 3eteD-2gf0A:
undetectable
3eteF-2gf0A:
undetectable		 3eteD-2gf0A:
16.97
3eteF-2gf0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 6 VAL A  10
LEU A  74
ILE A  48
ILE A  59
 None
 0.80A 3gcsA-2gf0A:
undetectable		 3gcsA-2gf0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		3 / 3 ARG A 170
TYR A   8
GLU A 168
 None
 0.65A 4zzbE-2gf0A:
undetectable		 4zzbE-2gf0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens) 		4 / 8 GLU A 159
CYH A 123
TYR A 155
PHE A 146
 None
 1.30A 5oajD-2gf0A:
0.0
5oajE-2gf0A:
0.0		 5oajD-2gf0A:
21.22
5oajE-2gf0A:
21.22