SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	2gf1	INSULIN-LIKE GROWTH FACTOR I (Homo sapiens)	4 / 8	TYR A 31 LEU A 14 VAL A 11 LEU A 10	None	0.88A	2w98B-2gf1A: undetectable	2w98B-2gf1A: 13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	2gf1	INSULIN-LIKE GROWTH FACTOR I (Homo sapiens)	3 / 3	LYS A 68 ARG A 55 ASP A 20	None	1.45A	3o7wA-2gf1A: undetectable	3o7wA-2gf1A: 15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_G_EVPG2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2gf1	INSULIN-LIKE GROWTH FACTOR I (Homo sapiens)	4 / 6	GLU A 9 GLY A 22 ARG A 21 GLY A 19	None	0.74A	5cdnA-2gf1A: undetectable 5cdnB-2gf1A: undetectable	5cdnA-2gf1A: 9.44 5cdnB-2gf1A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_O_EVPO2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2gf1	INSULIN-LIKE GROWTH FACTOR I (Homo sapiens)	4 / 6	GLU A 9 GLY A 22 ARG A 21 GLY A 19	None	0.61A	5cdnC-2gf1A: undetectable 5cdnD-2gf1A: undetectable	5cdnC-2gf1A: 9.44 5cdnD-2gf1A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_P_EVPP2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2gf1	INSULIN-LIKE GROWTH FACTOR I (Homo sapiens)	4 / 6	GLU A 9 GLY A 22 ARG A 21 GLY A 19	None	0.61A	5cdnT-2gf1A: undetectable 5cdnU-2gf1A: undetectable	5cdnT-2gf1A: 9.44 5cdnU-2gf1A: 18.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W98_B_P1ZB1356_1","PROSTAGLANDIN REDUCTASE 2","2gf1","INSULIN-LIKE GROWTH FACTOR I","Homo sapiens",4,"TYR A  31;LEU A  14;VAL A  11;LEU A  10","None","0.88A","2w98B-2gf1A:undetectable","2w98B-2gf1A:13.69"],["3O7W_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 1","2gf1","INSULIN-LIKE GROWTH FACTOR I","Homo sapiens",3,"LYS A  68;ARG A  55;ASP A  20","None","1.45A","3o7wA-2gf1A:undetectable","3o7wA-2gf1A:15.68"],["5CDN_G_EVPG2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","2gf1","INSULIN-LIKE GROWTH FACTOR I","Homo sapiens",4,"GLU A   9;GLY A  22;ARG A  21;GLY A  19","None","0.74A","5cdnA-2gf1A:undetectable;5cdnB-2gf1A:undetectable","5cdnA-2gf1A:9.44;5cdnB-2gf1A:18.18"],["5CDN_O_EVPO2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","2gf1","INSULIN-LIKE GROWTH FACTOR I","Homo sapiens",4,"GLU A   9;GLY A  22;ARG A  21;GLY A  19","None","0.61A","5cdnC-2gf1A:undetectable;5cdnD-2gf1A:undetectable","5cdnC-2gf1A:9.44;5cdnD-2gf1A:18.18"],["5CDN_P_EVPP2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","2gf1","INSULIN-LIKE GROWTH FACTOR I","Homo sapiens",4,"GLU A   9;GLY A  22;ARG A  21;GLY A  19","None","0.61A","5cdnT-2gf1A:undetectable;5cdnU-2gf1A:undetectable","5cdnT-2gf1A:9.44;5cdnU-2gf1A:18.18"]]