SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 221
LEU A 216
THR A 279
LEU A 286
THR A 223
 None
 1.13A 1ddsA-2gf2A:
2.3		 1ddsA-2gf2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ILE A 135
PHE A 154
GLY A 205
ILE A 210
 None
 0.87A 2qwxA-2gf2A:
6.5
2qwxB-2gf2A:
6.4		 2qwxA-2gf2A:
24.30
2qwxB-2gf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 GLY A 203
GLY A 176
GLY A 200
GLY A 205
 None
 0.58A 3bogC-2gf2A:
undetectable		 3bogC-2gf2A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 GLY A 203
GLY A 176
GLY A 200
GLY A 205
 None
 0.58A 3bogD-2gf2A:
undetectable		 3bogD-2gf2A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 PRO A  89
ALA A  93
ALA A  96
ILE A 119
 None
 0.63A 3dtuC-2gf2A:
undetectable
3dtuD-2gf2A:
undetectable		 3dtuC-2gf2A:
19.89
3dtuD-2gf2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 SER A 132
MET A 192
PHE A 173
ILE A 130
 None
 1.03A 3g59A-2gf2A:
1.7		 3g59A-2gf2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLU A 111
TYR A 113
ALA A 116
SER A 114
ALA A  93
 None
 1.33A 3nmuA-2gf2A:
undetectable
3nmuF-2gf2A:
5.6		 3nmuA-2gf2A:
21.41
3nmuF-2gf2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TYR A 198
ASP A 156
ASP A 136
 None
 0.85A 3ou6B-2gf2A:
4.3		 3ou6B-2gf2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A 129
ALA A  96
VAL A  86
ILE A  99
 None
 0.94A 3wsjB-2gf2A:
undetectable		 3wsjB-2gf2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A  46
GLY A  51
ILE A 100
LEU A 103
PRO A 104
 None
 1.03A 4gc9A-2gf2A:
4.0		 4gc9A-2gf2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ASP A 285
ASN A 212
SER A 133
 None
 0.82A 4obwA-2gf2A:
3.0		 4obwA-2gf2A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ILE A 135
PHE A 154
GLY A 205
ILE A 210
 None
 0.94A 4qogA-2gf2A:
6.6
4qogB-2gf2A:
6.4		 4qogA-2gf2A:
24.30
4qogB-2gf2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 221
LEU A 216
THR A 279
LEU A 286
THR A 223
 None
 1.04A 5e8qB-2gf2A:
2.5		 5e8qB-2gf2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 ALA A 207
THR A 204
CYH A 211
THR A 296
ASP A 136
 None
 1.21A 5lf3H-2gf2A:
undetectable
5lf3I-2gf2A:
undetectable		 5lf3H-2gf2A:
22.83
5lf3I-2gf2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 221
LEU A 216
THR A 279
LEU A 286
THR A 223
 None
 1.05A 5ujxB-2gf2A:
2.5		 5ujxB-2gf2A:
19.34