SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.42A 1a4gA-2gfgA:
undetectable		 1a4gA-2gfgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.41A 1a4gB-2gfgA:
undetectable		 1a4gB-2gfgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2gfg BH2851
(Bacillus
halodurans) 		5 / 10 LEU A 168
ILE A 167
LEU A  25
LEU A  21
VAL A  13
 None
 1.12A 1cqpA-2gfgA:
undetectable
1cqpB-2gfgA:
undetectable		 1cqpA-2gfgA:
21.74
1cqpB-2gfgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gfg BH2851
(Bacillus
halodurans) 		3 / 3 SER A 156
GLU A 157
GLU A 158
 EDO  A 504 (-4.6A)
None
None
 0.56A 1eqbD-2gfgA:
undetectable		 1eqbD-2gfgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gfg BH2851
(Bacillus
halodurans) 		3 / 3 SER A 156
GLU A 157
GLU A 158
 EDO  A 504 (-4.6A)
None
None
 0.56A 1eqbB-2gfgA:
undetectable		 1eqbB-2gfgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.46A 2cmlA-2gfgA:
undetectable		 2cmlA-2gfgA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.46A 2cmlC-2gfgA:
undetectable		 2cmlC-2gfgA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 7 TYR A  39
SER A 140
SER A 122
THR A 123
 None
 1.06A 2i91A-2gfgA:
undetectable		 2i91A-2gfgA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 7 TYR A  39
SER A 140
SER A 122
THR A 123
 None
 1.06A 2i91B-2gfgA:
undetectable		 2i91B-2gfgA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 8 LEU A  67
LEU A 108
ASP A 107
ASP A 103
 None
 0.99A 2j2pA-2gfgA:
undetectable
2j2pB-2gfgA:
undetectable		 2j2pA-2gfgA:
20.44
2j2pB-2gfgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ALA A 126
LEU A 135
LEU A  25
SER A  23
ILE A 173
 None
 1.06A 2oipE-2gfgA:
undetectable		 2oipE-2gfgA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 11 LEU A 135
ALA A 160
ILE A   7
THR A 170
GLU A 166
 None
EDO  A 504 ( 4.3A)
None
None
None
 1.36A 3qelA-2gfgA:
undetectable
3qelB-2gfgA:
undetectable		 3qelA-2gfgA:
19.11
3qelB-2gfgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.47A 3sanA-2gfgA:
undetectable		 3sanA-2gfgA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.47A 3sanB-2gfgA:
undetectable		 3sanB-2gfgA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 5 GLU A   8
ARG A  57
LYS A  68
ARG A 125
GLU A 151
 EDO  A 503 ( 3.9A)
UNL  A 500 ( 3.4A)
UNL  A 500 ( 3.7A)
UNL  A 500 (-3.6A)
UNL  A 500 ( 2.8A)
 0.83A 3tj7C-2gfgA:
25.8		 3tj7C-2gfgA:
45.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.43A 4cpnB-2gfgA:
undetectable		 4cpnB-2gfgA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.44A 4cpzA-2gfgA:
undetectable		 4cpzA-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.40A 4cpzB-2gfgA:
undetectable		 4cpzB-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.38A 4cpzC-2gfgA:
undetectable		 4cpzC-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.42A 4cpzD-2gfgA:
undetectable		 4cpzD-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.43A 4cpzE-2gfgA:
undetectable		 4cpzE-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.45A 4cpzG-2gfgA:
undetectable		 4cpzG-2gfgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 8 ILE A 128
ILE A 150
PHE A 152
GLY A 154
 None
None
EDO  A 504 ( 4.9A)
EDO  A 504 (-3.2A)
 0.95A 4hdlA-2gfgA:
undetectable		 4hdlA-2gfgA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ARG A 184
GLU A 149
GLU A 151
GLU A   6
GLU A   8
 EDO  A 503 (-4.2A)
EDO  A 503 (-3.0A)
UNL  A 500 ( 2.8A)
UNL  A 500 ( 3.9A)
EDO  A 503 ( 3.9A)
 1.48A 4i00A-2gfgA:
undetectable		 4i00A-2gfgA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 8 SER A 122
ARG A  55
TYR A  39
ARG A  57
 None
UNL  A 500 (-3.5A)
None
UNL  A 500 ( 3.4A)
 1.05A 4ijiF-2gfgA:
undetectable		 4ijiF-2gfgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2gfg BH2851
(Bacillus
halodurans) 		4 / 6 GLU A 153
ARG A 125
GLU A   8
GLU A   6
 UNL  A 500 ( 4.9A)
UNL  A 500 (-3.6A)
EDO  A 503 ( 3.9A)
UNL  A 500 ( 3.9A)
 1.35A 4kr3A-2gfgA:
undetectable		 4kr3A-2gfgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2gfg BH2851
(Bacillus
halodurans) 		3 / 3 VAL A  13
SER A  14
THR A  17
 None
 0.46A 4luhA-2gfgA:
undetectable		 4luhA-2gfgA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 LEU A 135
ALA A 160
ILE A   7
THR A 170
GLU A 166
 None
EDO  A 504 ( 4.3A)
None
None
None
 1.33A 5ewjC-2gfgA:
undetectable
5ewjD-2gfgA:
undetectable		 5ewjC-2gfgA:
19.02
5ewjD-2gfgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 12 ILE A  22
LEU A 137
PHE A  32
GLY A  30
GLY A  28
 None
None
EDO  A 502 (-3.9A)
None
None
 1.02A 5l6eA-2gfgA:
undetectable		 5l6eA-2gfgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2gfg BH2851
(Bacillus
halodurans) 		5 / 8 THR A 155
GLY A 154
ALA A 160
GLY A 133
GLU A 131
 EDO  A 504 (-4.3A)
EDO  A 504 (-3.2A)
EDO  A 504 ( 4.3A)
EDO  A 504 ( 4.4A)
None
 1.22A 5vw9A-2gfgA:
undetectable		 5vw9A-2gfgA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2gfg BH2851
(Bacillus
halodurans) 		3 / 3 ARG A 125
ARG A 184
ARG A  55
 UNL  A 500 (-3.6A)
EDO  A 503 (-4.2A)
UNL  A 500 (-3.5A)
 0.90A 6bplA-2gfgA:
undetectable
6bplB-2gfgA:
undetectable		 6bplA-2gfgA:
18.72
6bplB-2gfgA:
18.72