SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		4 / 8 LEU A  21
LEU A  14
SER A  39
GLU A  37
 None
 0.78A 1i7zA-2gfnA:
undetectable		 1i7zA-2gfnA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		4 / 6 ILE A  27
PRO A  96
LEU A 171
ILE A 174
 None
 1.04A 2q83B-2gfnA:
undetectable		 2q83B-2gfnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		3 / 3 VAL A  35
SER A  39
LEU A  46
 None
 0.68A 3n8xA-2gfnA:
0.9		 3n8xA-2gfnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 12 THR A 166
ASP A 167
VAL A 163
PHE A 128
TYR A 112
 None
 1.33A 3nyaA-2gfnA:
undetectable		 3nyaA-2gfnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 11 ALA A  36
SER A  52
LEU A  57
VAL A  18
THR A  43
 None
 1.44A 4eilA-2gfnA:
undetectable		 4eilA-2gfnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 10 ALA A  36
SER A  52
LEU A  57
VAL A  18
THR A  43
 None
 1.39A 4eilB-2gfnA:
undetectable		 4eilB-2gfnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 11 ALA A  36
SER A  52
LEU A  57
VAL A  18
THR A  43
 None
 1.44A 4eilC-2gfnA:
undetectable		 4eilC-2gfnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 11 ALA A  36
SER A  52
LEU A  57
VAL A  18
THR A  43
 None
 1.44A 4eilE-2gfnA:
undetectable		 4eilE-2gfnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		5 / 12 GLY A  65
GLN A  68
ALA A  64
SER A  93
ILE A  94
 None
 1.33A 4pb1A-2gfnA:
2.4		 4pb1A-2gfnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		3 / 3 LEU A 153
VAL A 193
ASP A 194
 None
 0.69A 4y8wC-2gfnA:
undetectable		 4y8wC-2gfnA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN
(Rhodococcus
jostii) 		4 / 7 GLU A  38
ARG A  24
GLU A  25
ALA A  29
 None
 1.07A 4zz8A-2gfnA:
undetectable		 4zz8A-2gfnA:
22.33