SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gfp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 6 ASP A  33
LEU A 238
GLY A 239
ILE A  26
 None
 0.87A 1mt1G-2gfpA:
undetectable
1mt1J-2gfpA:
undetectable		 1mt1G-2gfpA:
10.13
1mt1J-2gfpA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 7 ILE A  26
ASP A  33
LEU A 238
GLY A 239
 None
 0.90A 1mt1H-2gfpA:
undetectable
1mt1K-2gfpA:
undetectable		 1mt1H-2gfpA:
12.83
1mt1K-2gfpA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 ASP A  33
LEU A 238
GLY A 239
ILE A  26
 None
 0.88A 1n13A-2gfpA:
undetectable
1n13F-2gfpA:
undetectable		 1n13A-2gfpA:
10.13
1n13F-2gfpA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 12 LEU A  53
TYR A  52
TYR A  56
LEU A 216
LEU A 302
 None
 1.49A 1p33C-2gfpA:
undetectable		 1p33C-2gfpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 PHE A 257
ALA A 133
ILE A 253
ASN A 134
 None
 1.16A 1pnlA-2gfpA:
undetectable
1pnlB-2gfpA:
undetectable		 1pnlA-2gfpA:
18.47
1pnlB-2gfpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 12 TYR A 165
TYR A  52
ILE A  76
VAL A  19
ALA A  18
 None
 1.04A 1udtA-2gfpA:
undetectable		 1udtA-2gfpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 5 LEU A 302
LEU A 365
LEU A 367
LEU A 220
 None
 1.05A 1yajD-2gfpA:
undetectable		 1yajD-2gfpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 5 LEU A  10
LEU A   9
LEU A 120
LEU A 124
 None
 1.04A 2ab2B-2gfpA:
undetectable		 2ab2B-2gfpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 ILE A  26
ASP A  33
LEU A 238
GLY A 239
 None
 0.88A 2qqcH-2gfpA:
undetectable
2qqcK-2gfpA:
undetectable		 2qqcH-2gfpA:
13.45
2qqcK-2gfpA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 ILE A  26
ASP A  33
LEU A 238
GLY A 239
 None
 0.90A 2qqdB-2gfpA:
undetectable
2qqdC-2gfpA:
undetectable		 2qqdB-2gfpA:
13.45
2qqdC-2gfpA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 LEU A 216
LEU A 213
ALA A 221
LEU A  53
 None
 0.89A 2vcvF-2gfpA:
undetectable		 2vcvF-2gfpA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 VAL A  78
ARG A  73
SER A  59
VAL A  19
 None
 1.28A 2y05A-2gfpA:
undetectable
2y05B-2gfpA:
undetectable		 2y05A-2gfpA:
20.66
2y05B-2gfpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		3 / 3 MET A  22
MET A  80
PHE A 167
 None
 1.39A 3gn8A-2gfpA:
undetectable		 3gn8A-2gfpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		3 / 3 MET A  22
MET A 158
PHE A 167
 None
 1.20A 3gn8A-2gfpA:
undetectable		 3gn8A-2gfpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 7 ARG A  72
LEU A  16
LEU A  77
ILE A  76
 None
 0.89A 3s56B-2gfpA:
undetectable		 3s56B-2gfpA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 6 PHE A 328
LEU A 331
PRO A 329
GLU A 326
 None
 1.19A 3vlnA-2gfpA:
2.7		 3vlnA-2gfpA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 11 ALA A 173
MET A  84
PHE A  83
VAL A  19
THR A 176
 None
 1.43A 4kyaA-2gfpA:
undetectable		 4kyaA-2gfpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 10 ALA A 173
MET A  84
PHE A  83
VAL A  19
THR A 176
 None
 1.44A 4kyaC-2gfpA:
undetectable		 4kyaC-2gfpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 11 ALA A 173
MET A  84
PHE A  83
VAL A  19
THR A 176
 None
 1.44A 4kyaE-2gfpA:
undetectable		 4kyaE-2gfpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 11 ALA A 173
MET A  84
PHE A  83
VAL A  19
THR A 176
 None
 1.42A 4kyaG-2gfpA:
undetectable		 4kyaG-2gfpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 5 LEU A  16
ALA A  18
LEU A 169
VAL A 143
 None
 1.12A 5cr1A-2gfpA:
undetectable		 5cr1A-2gfpA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 12 GLY A 340
GLY A 218
GLY A 336
VAL A 299
ILE A 223
 None
 1.03A 5ehiC-2gfpA:
undetectable		 5ehiC-2gfpA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		5 / 12 ILE A 217
GLU A 326
ALA A 337
SER A 207
MET A 372
 None
 1.18A 5iwuA-2gfpA:
undetectable		 5iwuA-2gfpA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		6 / 12 LEU A 136
ALA A 307
VAL A 115
GLY A 114
ALA A 117
LEU A  13
 None
 1.49A 5jw1B-2gfpA:
undetectable		 5jw1B-2gfpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 8 ALA A  35
VAL A 245
TYR A  27
GLN A  24
 None
 0.95A 5nu7A-2gfpA:
undetectable		 5nu7A-2gfpA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		3 / 3 PHE A 328
ARG A 118
ALA A 306
 None
 0.87A 6ecfB-2gfpA:
undetectable		 6ecfB-2gfpA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2gfp MULTIDRUG RESISTANCE
PROTEIN D
(Escherichia
coli) 		4 / 7 ALA A 284
GLY A 285
LEU A 286
GLY A 295
 None
 0.79A 6nm4A-2gfpA:
undetectable		 6nm4A-2gfpA:
17.11