SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 8 ALA A 234
LEU A 219
GLU A 266
ALA A 260
THR A 256
 None
 1.34A 1ie4B-2gfqA:
undetectable
1ie4D-2gfqA:
undetectable		 1ie4B-2gfqA:
18.82
1ie4D-2gfqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 TYR A 200
GLU A 137
HIS A  80
HIS A 140
TYR A 102
 None
MG  A2018 ( 4.6A)
None
MG  A2018 ( 4.6A)
None
 1.45A 1ituA-2gfqA:
undetectable		 1ituA-2gfqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 TYR A 200
GLU A 137
HIS A  80
HIS A 140
TYR A 102
 None
MG  A2018 ( 4.6A)
None
MG  A2018 ( 4.6A)
None
 1.45A 1ituB-2gfqA:
undetectable		 1ituB-2gfqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		4 / 5 TYR A 102
PHE A 152
TYR A  55
PRO A 143
 None
MG  A2018 ( 4.6A)
None
None
 1.40A 1mclA-2gfqA:
0.0
1mclB-2gfqA:
0.0
1mclP-2gfqA:
undetectable		 1mclA-2gfqA:
21.90
1mclB-2gfqA:
21.90
1mclP-2gfqA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		4 / 7 TYR A 222
ASN A  96
TYR A 102
GLY A 104
 None
 1.12A 1mxgA-2gfqA:
undetectable		 1mxgA-2gfqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 ILE A  16
ILE A 175
LEU A 179
ILE A  73
ILE A   4
 None
 1.01A 1oipA-2gfqA:
undetectable		 1oipA-2gfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 7 ILE A  46
PRO A  71
ILE A  63
LEU A  59
ILE A  74
 None
 1.29A 2q83A-2gfqA:
undetectable		 2q83A-2gfqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		3 / 3 ARG A 253
GLU A 107
SER A 252
 None
 0.80A 2xkkA-2gfqA:
undetectable
2xkkC-2gfqA:
undetectable		 2xkkA-2gfqA:
17.23
2xkkC-2gfqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 9 LEU A 146
ILE A  74
ALA A  75
ALA A 110
THR A  94
 None
 0.91A 3mdvA-2gfqA:
undetectable		 3mdvA-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 LEU A 146
ILE A  74
ALA A  75
ALA A 110
THR A  94
 None
 0.92A 3mdvB-2gfqA:
undetectable		 3mdvB-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 11 GLU A 137
HIS A  80
ALA A 167
LEU A  89
THR A  90
 MG  A2018 ( 4.6A)
None
None
None
None
 1.19A 3mdzA-2gfqA:
undetectable		 3mdzA-2gfqA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		3 / 3 VAL A 148
SER A 150
LEU A 146
 None
 0.75A 3n8xA-2gfqA:
1.6		 3n8xA-2gfqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 ARG A 253
GLY A 197
GLY A 251
GLN A 224
ASP A 248
 None
 1.13A 3t7sA-2gfqA:
undetectable		 3t7sA-2gfqA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 ARG A 253
GLY A 197
GLY A 251
GLN A 224
ASP A 248
 None
 1.08A 3t7sB-2gfqA:
undetectable		 3t7sB-2gfqA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 12 ARG A 253
GLY A 197
GLY A 251
GLN A 224
ASP A 248
 None
 1.09A 3t7sD-2gfqA:
undetectable		 3t7sD-2gfqA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		3 / 3 LEU A 209
LYS A 206
THR A 205
 None
 0.45A 4lj0A-2gfqA:
undetectable		 4lj0A-2gfqA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		3 / 3 SER A 108
ALA A 110
VAL A 111
 None
 0.52A 4o2bA-2gfqA:
2.3		 4o2bA-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		3 / 3 SER A 108
ALA A 110
VAL A 111
 None
 0.67A 4o2bC-2gfqA:
2.2		 4o2bC-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		4 / 5 TYR A  56
GLU A  34
LEU A  59
GLN A  66
 None
 1.45A 4qztB-2gfqA:
undetectable		 4qztB-2gfqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 8 GLY A 196
VAL A 247
ALA A 260
LEU A 259
GLY A 254
 None
 1.29A 4zauA-2gfqA:
undetectable		 4zauA-2gfqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 8 ILE A 113
VAL A 226
ILE A 195
ILE A 245
PHE A 238
 None
 1.32A 5hi2A-2gfqA:
undetectable		 5hi2A-2gfqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		6 / 12 LEU A 179
LEU A  20
ALA A  77
ILE A 153
ALA A  75
ILE A  16
 None
 1.35A 5xiwB-2gfqA:
undetectable		 5xiwB-2gfqA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 11 THR A  94
GLU A 137
PHE A 152
SER A  78
THR A   7
 None
MG  A2018 ( 4.6A)
MG  A2018 ( 4.6A)
MG  A2018 ( 4.8A)
None
 1.43A 6efnA-2gfqA:
undetectable		 6efnA-2gfqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 9 THR A 144
GLY A 104
GLY A 103
HIS A 141
GLU A 107
 None
 1.34A 6gnfA-2gfqA:
undetectable		 6gnfA-2gfqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 2gfq UPF0204 PROTEIN
PH0006
(Pyrococcus
horikoshii) 		5 / 9 THR A 144
GLY A 104
GLY A 103
TRP A  97
HIS A 141
 None
 1.28A 6gnfA-2gfqA:
undetectable		 6gnfA-2gfqA:
23.51