SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ggs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A 106
THR A 107
GLU A 138
GLY A 137
 None
NDP  A 900 (-4.2A)
None
None
 1.21A 1icrA-2ggsA:
undetectable
1icrB-2ggsA:
undetectable		 1icrA-2ggsA:
24.01
1icrB-2ggsA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLU A 138
GLY A 137
SER A 106
THR A 107
 None
None
None
NDP  A 900 (-4.2A)
 1.20A 1icrA-2ggsA:
undetectable
1icrB-2ggsA:
undetectable		 1icrA-2ggsA:
24.01
1icrB-2ggsA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A 106
THR A 107
GLU A 138
GLY A 137
 None
NDP  A 900 (-4.2A)
None
None
 1.20A 1icvC-2ggsA:
undetectable
1icvD-2ggsA:
undetectable		 1icvC-2ggsA:
24.01
1icvD-2ggsA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLU A 138
GLY A 137
SER A 106
THR A 107
 None
None
None
NDP  A 900 (-4.2A)
 1.20A 1icvC-2ggsA:
undetectable
1icvD-2ggsA:
undetectable		 1icvC-2ggsA:
24.01
1icvD-2ggsA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLU A 138
GLY A 137
SER A 106
THR A 107
 None
None
None
NDP  A 900 (-4.2A)
 1.18A 1kqbA-2ggsA:
undetectable
1kqbB-2ggsA:
undetectable		 1kqbA-2ggsA:
23.94
1kqbB-2ggsA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 6 PRO A  58
LEU A  16
ILE A   5
SER A  21
 None
 1.15A 1sbrA-2ggsA:
undetectable
1sbrB-2ggsA:
undetectable		 1sbrA-2ggsA:
23.02
1sbrB-2ggsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 ALA A  64
ILE A 193
ILE A 149
ILE A 102
 NDP  A 900 (-4.3A)
None
None
None
 0.67A 1sh9A-2ggsA:
undetectable		 1sh9A-2ggsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A  90
ILE A  53
LEU A  41
 None
 0.70A 2kceA-2ggsA:
undetectable		 2kceA-2ggsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A  62
ILE A 149
LEU A  49
 None
 0.54A 2prgA-2ggsA:
undetectable		 2prgA-2ggsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 9 ALA A 255
VAL A 207
GLY A 209
LEU A 259
ALA A 192
 None
 0.90A 2z0yA-2ggsA:
undetectable		 2z0yA-2ggsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A  39
GLY A  38
ALA A  65
PHE A  52
LEU A  43
 None
None
NDP  A 900 (-3.7A)
None
NDP  A 900 (-3.8A)
 1.17A 3vywA-2ggsA:
2.7		 3vywA-2ggsA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A  39
GLY A  38
ALA A  65
PHE A  52
LEU A  43
 None
None
NDP  A 900 (-3.7A)
None
NDP  A 900 (-3.8A)
 1.18A 3vywB-2ggsA:
undetectable		 3vywB-2ggsA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.04A 4e47A-2ggsA:
undetectable		 4e47A-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.05A 4e47B-2ggsA:
undetectable		 4e47B-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.07A 4e47C-2ggsA:
undetectable		 4e47C-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.06A 4jdsA-2ggsA:
undetectable		 4jdsA-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.05A 4jdsB-2ggsA:
undetectable		 4jdsB-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.08A 4jdsC-2ggsA:
undetectable		 4jdsC-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.07A 4jlgA-2ggsA:
undetectable		 4jlgA-2ggsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  18
LEU A  19
GLU A  22
 None
 0.70A 4l3gF-2ggsA:
undetectable		 4l3gF-2ggsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A  21
SER A  17
ILE A  35
GLU A  15
 None
 1.36A 4ms4A-2ggsA:
4.6		 4ms4A-2ggsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 208
GLY A 209
GLU A 210
GLY A 116
ASN A 117
 None
 1.08A 5ayfA-2ggsA:
undetectable		 5ayfA-2ggsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 270
ARG A 187
PHE A 160
TYR A 181
TYR A 165
 None
 1.28A 5czyA-2ggsA:
undetectable		 5czyA-2ggsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A 199
LEU A 196
SER A 260
ALA A 192
 None
 1.03A 5uunA-2ggsA:
undetectable		 5uunA-2ggsA:
24.30