SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ggt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ILE A 162
ILE A 201
THR A 197
 None
 0.61A 1rg7A-2ggtA:
undetectable		 1rg7A-2ggtA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 177
TYR A 163
PHE A 200
TYR A 216
 None
 1.16A 3po7A-2ggtA:
undetectable		 3po7A-2ggtA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 265
MET A 264
ILE A 181
 None
 0.88A 4c8bB-2ggtA:
undetectable		 4c8bB-2ggtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 145
VAL A 234
LEU A 142
 None
 0.57A 4m2vA-2ggtA:
undetectable		 4m2vA-2ggtA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 162
ILE A 203
SER A 202
LEU A 142
 None
 0.98A 4m51A-2ggtA:
undetectable		 4m51A-2ggtA:
17.41