SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ggz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 12 THR A  62
VAL A  59
LEU A  43
LEU A  82
ILE A  83
 None
 1.25A 1kqwA-2ggzA:
undetectable		 1kqwA-2ggzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 8 LEU A  82
LEU A  98
VAL A  59
VAL A 177
 None
 1.02A 2bdmA-2ggzA:
undetectable		 2bdmA-2ggzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 7 MET A 115
VAL A 168
ILE A 167
TYR A  99
 None
 1.00A 2yfbA-2ggzA:
undetectable		 2yfbA-2ggzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 12 GLY A 157
VAL A 168
LEU A 165
ILE A 143
ASP A 142
 None
None
None
None
CA  A 502 (-3.1A)
 1.30A 3cjtK-2ggzA:
undetectable		 3cjtK-2ggzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLY A 157
ILE A 167
VAL A 168
 None
 0.50A 3nv6A-2ggzA:
undetectable		 3nv6A-2ggzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLN A  85
GLU A  89
LYS A  87
 None
 1.09A 3su9A-2ggzA:
undetectable		 3su9A-2ggzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 11 PHE A 174
THR A  62
PHE A  63
VAL A 168
PHE A 154
 None
 1.05A 3u9fA-2ggzA:
0.0
3u9fC-2ggzA:
0.0		 3u9fA-2ggzA:
21.22
3u9fC-2ggzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 12 PHE A 174
THR A  62
PHE A  63
VAL A 168
PHE A 154
 None
 1.12A 3u9fJ-2ggzA:
0.0
3u9fL-2ggzA:
0.0		 3u9fJ-2ggzA:
21.22
3u9fL-2ggzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 11 THR A  62
PHE A  63
VAL A 168
PHE A 154
PHE A 174
 None
 1.05A 3u9fN-2ggzA:
undetectable
3u9fO-2ggzA:
undetectable		 3u9fN-2ggzA:
21.22
3u9fO-2ggzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 11 PHE A 174
THR A  62
PHE A  63
VAL A 168
PHE A 154
 None
 1.05A 3u9fM-2ggzA:
0.0
3u9fO-2ggzA:
0.0		 3u9fM-2ggzA:
21.22
3u9fO-2ggzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 12 PHE A 174
THR A  62
PHE A  63
VAL A 168
PHE A 154
 None
 1.05A 3u9fP-2ggzA:
undetectable
3u9fS-2ggzA:
undetectable		 3u9fP-2ggzA:
21.22
3u9fS-2ggzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 10 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.29A 6mb7A-2ggzA:
undetectable		 6mb7A-2ggzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 10 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.35A 6mb9B-2ggzA:
undetectable		 6mb9B-2ggzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 10 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.31A 6mb9C-2ggzA:
undetectable		 6mb9C-2ggzA:
17.33