SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 TYR A  41
ALA A  92
MET A 147
GLY A 353
HIS A  42
 GAD  A1002 ( 4.1A)
None
GAD  A1002 ( 4.3A)
None
RAM  A1001 (-3.9A)
 1.17A 1kiaB-2gh4A:
undetectable		 1kiaB-2gh4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		3 / 3 LEU A 260
HIS A 314
LYS A 315
 None
 1.02A 1y7iA-2gh4A:
undetectable		 1y7iA-2gh4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 11 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.25A 1yatA-2gh4A:
undetectable		 1yatA-2gh4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 9 ASP A 255
LEU A 260
GLY A 259
TYR A 262
THR A 316
 None
 1.44A 2tsrD-2gh4A:
undetectable		 2tsrD-2gh4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 8 ALA A 307
LEU A 260
ILE A 312
VAL A 326
ILE A 329
 None
 1.42A 2uxpA-2gh4A:
undetectable		 2uxpA-2gh4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 11 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.23A 2vn1A-2gh4A:
undetectable		 2vn1A-2gh4A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 11 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.29A 3vawA-2gh4A:
undetectable		 3vawA-2gh4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 7 TRP A 141
HIS A 132
TYR A 136
TYR A 340
 None
GAD  A1002 (-3.9A)
None
None
 1.39A 4a3uA-2gh4A:
undetectable		 4a3uA-2gh4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 7 TRP A 141
HIS A 132
TYR A 136
TYR A 340
 None
GAD  A1002 (-3.9A)
None
None
 1.46A 4a3uB-2gh4A:
undetectable		 4a3uB-2gh4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 11 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.22A 4driA-2gh4A:
undetectable		 4driA-2gh4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 10 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.41A 4dz3A-2gh4A:
undetectable		 4dz3A-2gh4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 10 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.24A 4dz3B-2gh4A:
undetectable		 4dz3B-2gh4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		3 / 3 ASP A 350
TRP A 141
SER A 278
 None
 1.08A 4lrhA-2gh4A:
undetectable		 4lrhA-2gh4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 ALA A 307
TYR A 308
PHE A 324
PHE A 357
THR A 316
 None
 1.33A 4mm4A-2gh4A:
undetectable		 4mm4A-2gh4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 ALA A 307
TYR A 308
PHE A 324
PHE A 357
THR A 316
 None
 1.25A 4mm4B-2gh4A:
undetectable		 4mm4B-2gh4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 ALA A 354
LEU A 351
LEU A  47
GLY A  49
VAL A  50
 None
 0.73A 4o33A-2gh4A:
undetectable		 4o33A-2gh4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 ALA A 354
LEU A 351
LEU A  47
GLY A  49
VAL A  50
 None
 0.78A 4o3fA-2gh4A:
undetectable		 4o3fA-2gh4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		3 / 3 TYR A 295
LYS A 289
LYS A 293
 None
 1.32A 5dbyA-2gh4A:
undetectable		 5dbyA-2gh4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 11 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.30A 5hwcA-2gh4A:
undetectable		 5hwcA-2gh4A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 8 THR A 316
SER A 277
SER A 280
ASP A 255
 None
 1.00A 5l5fY-2gh4A:
undetectable
5l5fZ-2gh4A:
undetectable		 5l5fY-2gh4A:
21.21
5l5fZ-2gh4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 4 GLN A 102
THR A 103
LEU A  47
LEU A  51
 None
 1.23A 5m5kB-2gh4A:
undetectable		 5m5kB-2gh4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 4 VAL A 109
LEU A  96
LEU A  99
ASP A  71
 None
 1.40A 5xv7A-2gh4A:
undetectable		 5xv7A-2gh4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 10 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
 None
 1.26A 6mkeC-2gh4A:
undetectable		 6mkeC-2gh4A:
12.93