SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ghb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 149
GLY A 145
GLY A 144
LEU A 207
LEU A 132
 None
 0.86A 1eizA-2ghbA:
undetectable		 1eizA-2ghbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A  83
LEU A 284
ALA A 289
SER A 306
GLY A 105
 None
 1.14A 1kglA-2ghbA:
undetectable		 1kglA-2ghbA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 PHE A 323
TYR A 245
TYR A 238
 None
 1.03A 1x70B-2ghbA:
undetectable		 1x70B-2ghbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 THR A 293
GLY A 300
GLN A  15
ILE A 288
PHE A 268
 None
 1.34A 2azxA-2ghbA:
undetectable		 2azxA-2ghbA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 7 LYS A 102
LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.38A 2dysC-2ghbA:
undetectable
2dysJ-2ghbA:
undetectable		 2dysC-2ghbA:
19.69
2dysJ-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A  22
GLY A  23
LEU A  19
ILE A   9
LEU A 284
 None
 1.00A 2f8dA-2ghbA:
3.5		 2f8dA-2ghbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A  22
GLY A  23
LEU A  19
ILE A   9
LEU A 284
 None
 1.02A 2f8dB-2ghbA:
6.0		 2f8dB-2ghbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 259
GLY A 166
GLY A 194
ASN A 329
SER A 326
 None
 1.10A 2okcB-2ghbA:
undetectable		 2okcB-2ghbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  86
PHE A  83
LEU A 103
SER A  98
VAL A  68
 None
 1.38A 2po5B-2ghbA:
undetectable		 2po5B-2ghbA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ALA A 114
GLY A 264
SER A 326
ALA A 327
 None
 0.92A 2vh3B-2ghbA:
undetectable		 2vh3B-2ghbA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.00A 2zxwC-2ghbA:
undetectable
2zxwJ-2ghbA:
undetectable		 2zxwC-2ghbA:
19.69
2zxwJ-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 149
GLY A 145
GLY A 144
LEU A 207
ALA A 136
 None
 0.85A 3douA-2ghbA:
undetectable		 3douA-2ghbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 229
PHE A 157
PHE A 262
GLY A 231
 None
 0.99A 3em0B-2ghbA:
undetectable		 3em0B-2ghbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.89A 3fpjA-2ghbA:
undetectable		 3fpjA-2ghbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 THR A  92
ASN A 329
TYR A 158
TRP A 343
 None
 1.43A 3jzjA-2ghbA:
19.0		 3jzjA-2ghbA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 GLY A 242
PHE A 150
PHE A 220
GLY A 223
 None
 0.99A 3ko0M-2ghbA:
0.0
3ko0P-2ghbA:
undetectable		 3ko0M-2ghbA:
14.02
3ko0P-2ghbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ALA A  52
ILE A  77
LEU A  71
ASN A 271
 None
 1.17A 4g19A-2ghbA:
undetectable		 4g19A-2ghbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 267
GLY A  63
ILE A 106
ARG A 303
LEU A  94
 None
 1.05A 4mwzB-2ghbA:
undetectable		 4mwzB-2ghbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 169
GLY A 168
GLY A 194
SER A 153
TYR A 159
 None
 1.04A 4rtmA-2ghbA:
undetectable		 4rtmA-2ghbA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 ALA A 191
ALA A 187
VAL A 368
LEU A 364
LEU A 350
 None
 1.24A 5eb5A-2ghbA:
undetectable		 5eb5A-2ghbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.08A 5iy5P-2ghbA:
undetectable
5iy5W-2ghbA:
undetectable		 5iy5P-2ghbA:
19.42
5iy5W-2ghbA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 MET A 129
LEU A 132
ARG A 148
PHE A 150
LEU A 198
 None
 1.34A 5uc3B-2ghbA:
undetectable		 5uc3B-2ghbA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 PHE A 157
ALA A 191
GLY A 168
TYR A 167
 None
 0.92A 5uxdA-2ghbA:
undetectable		 5uxdA-2ghbA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A 265
PRO A 332
ILE A 331
SER A  98
 None
 0.96A 5vkqA-2ghbA:
undetectable
5vkqD-2ghbA:
undetectable		 5vkqA-2ghbA:
12.59
5vkqD-2ghbA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.06A 5w97C-2ghbA:
undetectable
5w97J-2ghbA:
undetectable		 5w97C-2ghbA:
19.69
5w97J-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.09A 5x1fC-2ghbA:
undetectable
5x1fJ-2ghbA:
undetectable		 5x1fC-2ghbA:
19.69
5x1fJ-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.04A 5xdxC-2ghbA:
undetectable
5xdxJ-2ghbA:
undetectable		 5xdxC-2ghbA:
19.68
5xdxJ-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 103
PHE A  97
LEU A  86
PHE A  83
 None
 1.11A 5xdxP-2ghbA:
undetectable
5xdxW-2ghbA:
undetectable		 5xdxP-2ghbA:
19.68
5xdxW-2ghbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		6 / 12 LEU A 279
GLY A  23
ILE A 288
VAL A  34
LEU A   7
ILE A   9
 None
 1.23A 6ecxA-2ghbA:
undetectable		 6ecxA-2ghbA:
19.80