SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ghp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		4 / 5 ARG A  89
ALA A  88
ASP A  91
GLY A  65
 None
 0.89A 1e7bA-2ghpA:
undetectable		 1e7bA-2ghpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		4 / 5 ARG A  89
ALA A  88
ASP A  91
GLY A  65
 None
 1.09A 1e7cA-2ghpA:
undetectable		 1e7cA-2ghpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 133
ARG A  84
THR A 118
LEU A 119
 None
 1.05A 3ablA-2ghpA:
undetectable
3ablJ-2ghpA:
undetectable		 3ablA-2ghpA:
19.49
3ablJ-2ghpA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 281
ILE A 282
GLU A 267
VAL A 189
 None
 0.83A 4ejwB-2ghpA:
undetectable		 4ejwB-2ghpA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 110
VAL A  57
ASN A  47
LEU A  48
PRO A  49
 None
 0.95A 4gc9A-2ghpA:
undetectable		 4gc9A-2ghpA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 268
ASP A 264
TRP A 120
 None
 1.17A 4xdqA-2ghpA:
undetectable		 4xdqA-2ghpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 237
GLY A 235
PHE A 234
ARG A 210
LEU A 286
 None
 1.18A 5ergB-2ghpA:
undetectable		 5ergB-2ghpA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 165
ASP A 164
LEU A 178
ARG A 268
ARG A 134
 None
 1.26A 5nd3B-2ghpA:
undetectable		 5nd3B-2ghpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 165
ASP A 164
LEU A 178
ARG A 268
ARG A 134
 None
 1.20A 5nd4B-2ghpA:
undetectable		 5nd4B-2ghpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 286
ALA A 287
LEU A 270
 None
 0.40A 5uunB-2ghpA:
undetectable		 5uunB-2ghpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24
(Saccharomyces
cerevisiae) 		4 / 4 VAL A  45
LEU A  44
LEU A 114
ASP A 164
 None
 1.01A 5xv7A-2ghpA:
undetectable		 5xv7A-2ghpA:
13.33