SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ghw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1H8S_A_AICA1000_1 (MUTANT AL2 6E7P9G)	2ghw	ANTI-SARS SCFV ANTIBODY, 80R (Homo sapiens)	6 / 12	TYR B 168 GLN B 221 PHE B 230 VAL B 37 ALA B 97 TRP B 107	None	0.64A	1h8sA-2ghwB: 22.1	1h8sA-2ghwB: 34.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OLD_B_IPHB2001_0 (BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN)	2ghw	ANTI-SARS SCFV ANTIBODY, 80R (Homo sapiens)	4 / 7	TYR B 168 PRO B 176 TYR B 219 TYR B 95	None	0.72A	2oldA-2ghwB: 17.5 2oldB-2ghwB: 17.4	2oldA-2ghwB: 27.34 2oldB-2ghwB: 27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2ghw	ANTI-SARS SCFV ANTIBODY, 80R (Homo sapiens)	4 / 8	LEU B 179 LEU B 210 ILE B 190 PHE B 194	None	0.89A	3ln1A-2ghwB: undetectable	3ln1A-2ghwB: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2ghw	ANTI-SARS SCFV ANTIBODY, 80R (Homo sapiens)	4 / 7	LEU B 179 LEU B 210 ILE B 190 PHE B 194	None	0.88A	3ln1B-2ghwB: undetectable	3ln1B-2ghwB: 14.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H8S_A_AICA1000_1","MUTANT AL2 6E7P9G","2ghw","ANTI-SARS SCFV ANTIBODY, 80R","Homo sapiens",6,"TYR B 168;GLN B 221;PHE B 230;VAL B  37;ALA B  97;TRP B 107","None","0.64A","1h8sA-2ghwB:22.1","1h8sA-2ghwB:34.91"],["2OLD_B_IPHB2001_0","BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN","2ghw","ANTI-SARS SCFV ANTIBODY, 80R","Homo sapiens",4,"TYR B 168;PRO B 176;TYR B 219;TYR B  95","None","0.72A","2oldA-2ghwB:17.5;2oldB-2ghwB:17.4","2oldA-2ghwB:27.34;2oldB-2ghwB:27.34"],["3LN1_A_CELA682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2ghw","ANTI-SARS SCFV ANTIBODY, 80R","Homo sapiens",4,"LEU B 179;LEU B 210;ILE B 190;PHE B 194","None","0.89A","3ln1A-2ghwB:undetectable","3ln1A-2ghwB:14.72"],["3LN1_B_CELB682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2ghw","ANTI-SARS SCFV ANTIBODY, 80R","Homo sapiens",4,"LEU B 179;LEU B 210;ILE B 190;PHE B 194","None","0.88A","3ln1B-2ghwB:undetectable","3ln1B-2ghwB:14.72"]]