SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		5 / 11 LEU A  42
LEU A  83
ALA A  12
MET A  58
LEU A  39
 SO4  A 203 ( 4.9A)
None
None
None
SO4  A 204 (-4.9A)
 1.35A 1iiuA-2gi7A:
undetectable		 1iiuA-2gi7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 166
ASP A 121
ASP A 167
 None
 0.87A 3jayA-2gi7A:
undetectable		 3jayA-2gi7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 166
ASP A 121
ASP A 167
 None
 0.82A 3jb2A-2gi7A:
undetectable		 3jb2A-2gi7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 166
ASP A 121
ASP A 167
 None
 0.85A 3jb3A-2gi7A:
undetectable		 3jb3A-2gi7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 110
ALA A  98
LEU A  96
SER A 155
VAL A 150
 None
 1.11A 4eckB-2gi7A:
undetectable		 4eckB-2gi7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		4 / 5 PRO A  23
VAL A  24
ALA A  57
PHE A  54
 None
 1.17A 4z4cA-2gi7A:
undetectable		 4z4cA-2gi7A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2gi7 GPVI PROTEIN
(Homo
sapiens) 		4 / 6 VAL A  18
LEU A  85
LEU A  83
LEU A  53
 None
None
None
SO4  A 204 (-3.8A)
 1.06A 6f6sA-2gi7A:
undetectable
6f6sB-2gi7A:
undetectable		 6f6sA-2gi7A:
21.74
6f6sB-2gi7A:
16.30