SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		5 / 12 PHE B 118
LEU B 154
TYR B 125
LEU B  56
LEU B  93
 None
 1.30A 1e7wA-2gidB:
undetectable		 1e7wA-2gidB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		5 / 12 PHE B 118
LEU B 154
TYR B 125
LEU B  56
LEU B  93
 None
 1.33A 1p33A-2gidB:
undetectable		 1p33A-2gidB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		5 / 12 PHE B 118
LEU B 154
TYR B 125
LEU B  56
LEU B  93
 None
 1.26A 1p33B-2gidB:
undetectable		 1p33B-2gidB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		3 / 3 ARG B  48
VAL B  37
GLY B  65
 None
 0.65A 2avvE-2gidB:
undetectable		 2avvE-2gidB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		4 / 8 LEU B  88
LEU B 154
VAL B  99
GLY B  98
 None
 0.94A 2po5A-2gidB:
undetectable		 2po5A-2gidB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		5 / 9 MET B 109
LEU B  88
LEU B 154
VAL B  99
GLY B  98
 None
 1.24A 2po7A-2gidB:
0.0		 2po7A-2gidB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		5 / 9 MET B 109
LEU B  88
LEU B 154
VAL B  99
GLY B  98
 None
 1.27A 2po7B-2gidB:
0.0		 2po7B-2gidB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		4 / 8 MET B 109
LEU B  88
VAL B  99
GLY B  98
 None
 1.04A 2qd5A-2gidB:
undetectable		 2qd5A-2gidB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		4 / 7 LEU B  56
LEU B  57
SER B  85
VAL B 144
 None
 1.00A 3d2tA-2gidB:
undetectable		 3d2tA-2gidB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		4 / 6 ARG B  83
ILE B  84
VAL B 134
HIS B 132
 None
 0.98A 3deuA-2gidB:
0.6		 3deuA-2gidB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1
(Trypanosoma
brucei) 		4 / 5 ARG B  83
ILE B  84
VAL B 134
HIS B 132
 None
 1.03A 3deuB-2gidB:
0.0		 3deuB-2gidB:
19.39