SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		4 / 7 LEU A  79
LEU A  60
TYR A 123
LEU A  86
 None
 1.10A 1kt3A-2gieA:
undetectable		 1kt3A-2gieA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 LYS A   2
LYS A   5
PRO A   6
 None
 1.22A 4dv1L-2gieA:
undetectable		 4dv1L-2gieA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		4 / 6 PHE A  80
TYR A  59
LEU A  60
THR A  96
 None
 1.11A 4paeA-2gieA:
undetectable		 4paeA-2gieA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 ARG A  91
ASP A 111
TYR A  57
 None
 0.94A 4yo9B-2gieA:
undetectable		 4yo9B-2gieA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		4 / 7 LEU A  89
THR A  84
LEU A  85
THR A 112
 None
 0.87A 4z90A-2gieA:
undetectable
4z90B-2gieA:
undetectable
4z90C-2gieA:
undetectable
4z90D-2gieA:
undetectable
4z90E-2gieA:
undetectable		 4z90A-2gieA:
22.32
4z90B-2gieA:
22.32
4z90C-2gieA:
22.32
4z90D-2gieA:
22.32
4z90E-2gieA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 PHE A 164
ILE A 166
ASP A 114
 None
 0.66A 5cswA-2gieA:
undetectable		 5cswA-2gieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 PHE A 164
ILE A 166
ASP A 114
 None
 0.66A 5cswB-2gieA:
undetectable		 5cswB-2gieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 VAL A 171
GLN A  18
CYH A 182
 None
 0.71A 5icxA-2gieA:
undetectable
5icxE-2gieA:
undetectable		 5icxA-2gieA:
18.25
5icxE-2gieA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		5 / 12 ALA A  33
GLY A  34
LYS A  19
GLN A  18
LEU A  15
 None
 0.89A 5nwuA-2gieA:
undetectable		 5nwuA-2gieA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2gie TYPE II RESTRICTION
ENZYME HINCII
(Haemophilus
influenzae) 		3 / 3 LEU A 169
ASN A  48
LEU A 117
 None
 0.65A 6exiA-2gieA:
undetectable		 6exiA-2gieA:
14.56