SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		5 / 10 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.39A 1fohA-2gixA:
undetectable		 1fohA-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		5 / 10 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.40A 1fohB-2gixA:
undetectable		 1fohB-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		5 / 10 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.39A 1fohC-2gixA:
undetectable		 1fohC-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		5 / 10 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.35A 1fohD-2gixA:
undetectable		 1fohD-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		4 / 4 ILE A 248
ASP A 291
LEU A 282
ARG A 235
 None
 1.33A 2a7qA-2gixA:
undetectable		 2a7qA-2gixA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		4 / 5 ILE A 297
ILE A 269
HIS A 271
VAL A 252
 None
 1.02A 5jmnA-2gixA:
undetectable		 5jmnA-2gixA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2
(Mus
musculus) 		4 / 6 ASN A 198
LEU A 321
ARG A 325
GLY A 323
 None
 0.84A 5o4yA-2gixA:
undetectable		 5o4yA-2gixA:
5.26