SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2
(Trypanosoma
brucei) 		3 / 3 PHE A 156
LEU A 205
LEU A 209
 None
 0.66A 1mx1E-2gjeA:
undetectable		 1mx1E-2gjeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2
(Trypanosoma
brucei) 		4 / 6 LEU A 205
PHE A 197
ASP A 198
HIS A  89
 None
 1.01A 5om3A-2gjeA:
undetectable
5om3B-2gjeA:
undetectable		 5om3A-2gjeA:
17.02
5om3B-2gjeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2
(Trypanosoma
brucei) 		4 / 6 HIS A  79
MET A 204
ASN A 159
VAL A 199
 None
 1.06A 5xdhA-2gjeA:
undetectable
5xdhC-2gjeA:
undetectable		 5xdhA-2gjeA:
19.80
5xdhC-2gjeA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2
(Trypanosoma
brucei) 		4 / 5 HIS A  79
MET A 204
ASN A 159
VAL A 199
 None
 1.14A 5xdhB-2gjeA:
undetectable		 5xdhB-2gjeA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2
(Trypanosoma
brucei) 		4 / 5 HIS A  79
MET A 204
ASN A 159
VAL A 199
 None
 1.07A 5xdhD-2gjeA:
undetectable		 5xdhD-2gjeA:
19.80