SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		5 / 9 GLY A1130
ILE A1133
VAL A1092
ILE A1083
VAL A1065
 None
 0.85A 2nnhB-2gjtA:
undetectable		 2nnhB-2gjtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		3 / 3 ASN A 966
ASN A 994
ARG A1175
 None
 0.68A 2rlcA-2gjtA:
undetectable		 2rlcA-2gjtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		3 / 3 ARG A 978
ASP A1020
ASN A 962
 None
 0.77A 2zzmA-2gjtA:
undetectable		 2zzmA-2gjtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		5 / 12 GLN A1184
THR A1181
PHE A1187
GLY A1144
LEU A1152
 None
None
CL  A 305 ( 4.8A)
None
None
 1.45A 3aodC-2gjtA:
1.6		 3aodC-2gjtA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		4 / 8 ILE A1114
LEU A1149
VAL A1179
GLY A1141
 None
 0.90A 3w1wA-2gjtA:
undetectable		 3w1wA-2gjtA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		5 / 12 TYR A 997
GLN A1027
LEU A 981
VAL A 979
ILE A 993
 None
 1.25A 4k38A-2gjtA:
undetectable
4k38D-2gjtA:
undetectable		 4k38A-2gjtA:
19.74
4k38D-2gjtA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		5 / 12 TYR A 997
GLN A1027
LEU A 981
VAL A 979
ILE A 993
 None
 1.20A 4k39A-2gjtA:
undetectable		 4k39A-2gjtA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		3 / 3 MET A1024
MET A 984
TYR A 992
 None
 1.42A 4p6xI-2gjtA:
undetectable		 4p6xI-2gjtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		3 / 3 GLU A1041
TRP A1100
ASN A1096
 None
 1.13A 5dv4A-2gjtA:
undetectable		 5dv4A-2gjtA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens) 		3 / 3 ARG A 967
ARG A1142
ARG A1044
 None
 1.01A 5vcgA-2gjtA:
undetectable		 5vcgA-2gjtA:
19.38