SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 238
LEU A 246
ALA A 205
VAL A 242
LEU A  46
 None
 1.43A 1kt7A-2gjuA:
undetectable		 1kt7A-2gjuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  41
GLY A  71
GLY A 139
VAL A  44
ILE A  10
 None
 0.92A 2b25A-2gjuA:
undetectable		 2b25A-2gjuA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 197
PHE A 145
ILE A 123
ALA A   8
ARG A 177
 None
 1.17A 2j0dA-2gjuA:
undetectable		 2j0dA-2gjuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.18A 2y7kC-2gjuA:
undetectable		 2y7kC-2gjuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.22A 2y7kD-2gjuA:
undetectable		 2y7kD-2gjuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.92A 3ln1A-2gjuA:
undetectable		 3ln1A-2gjuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.92A 3ln1B-2gjuA:
undetectable		 3ln1B-2gjuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLY A 114
ILE A  43
VAL A  44
 None
 0.48A 3nv6A-2gjuA:
undetectable		 3nv6A-2gjuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ALA A 208
VAL A   6
LEU A  40
LEU A 180
 None
 0.78A 3roxA-2gjuA:
undetectable		 3roxA-2gjuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 161
GLY A 147
TYR A 138
VAL A 173
ALA A 174
 None
 1.18A 4fqsA-2gjuA:
undetectable		 4fqsA-2gjuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 161
GLY A 147
TYR A 138
VAL A 173
ALA A 174
 None
 1.17A 4fqsB-2gjuA:
undetectable		 4fqsB-2gjuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 HIS A  98
GLY A 250
ILE A 245
 None
 0.58A 4k50A-2gjuA:
undetectable		 4k50A-2gjuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 HIS A  98
GLY A 250
ILE A 245
 None
 0.57A 4k50I-2gjuA:
undetectable		 4k50I-2gjuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.54A 4x1iA-2gjuA:
undetectable		 4x1iA-2gjuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.50A 4x20C-2gjuA:
undetectable		 4x20C-2gjuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 LEU A 118
LEU A   7
ILE A  10
VAL A  68
VAL A  66
LEU A  60
 None
 1.35A 4y0qA-2gjuA:
undetectable		 4y0qA-2gjuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A  16
ALA A 205
ILE A 195
LEU A   7
 None
 0.79A 5jncD-2gjuA:
undetectable		 5jncD-2gjuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A  53
GLU A  52
LEU A  99
LEU A  46
ARG A 232
 None
None
PO4  A3005 (-4.5A)
None
None
 1.14A 5nd3B-2gjuA:
undetectable		 5nd3B-2gjuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 2gju 252AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ASN A  13
PRO A  15
GLU A  52
PHE A  14
 None
 1.48A 5oh1C-2gjuA:
undetectable		 5oh1C-2gjuA:
17.79