SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.08A 1jffB-2gjxA:
undetectable		 1jffB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 11 LEU A 172
VAL A 192
PRO A 471
LEU A 473
PRO A 475
 None
 1.21A 1klmA-2gjxA:
undetectable		 1klmA-2gjxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ILE A 356
LEU A 359
VAL A 363
 None
 0.27A 1mz9B-2gjxA:
undetectable		 1mz9B-2gjxA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 6 LEU A 273
TRP A 266
LEU A 221
PHE A 304
 None
 1.30A 1rukH-2gjxA:
undetectable
1rukL-2gjxA:
undetectable		 1rukH-2gjxA:
17.38
1rukL-2gjxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 2hxfB-2gjxA:
undetectable		 2hxfB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 2hxhB-2gjxA:
undetectable		 2hxhB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 6 PRO A 182
HIS A 179
ASP A 207
TYR A 180
 None
 1.41A 2lh8A-2gjxA:
undetectable		 2lh8A-2gjxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 2p4nB-2gjxA:
undetectable		 2p4nB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 6 PHE A  65
ALA A 135
LEU A 136
ALA A  64
 None
 0.90A 2vcvB-2gjxA:
undetectable		 2vcvB-2gjxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 6 PHE A  65
ALA A 135
LEU A 136
ALA A  64
 None
 0.93A 2vcvK-2gjxA:
undetectable		 2vcvK-2gjxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 2wbeB-2gjxA:
undetectable		 2wbeB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 VAL A 512
ASN A 196
TRP A  24
 None
 1.04A 2y00B-2gjxA:
undetectable		 2y00B-2gjxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.08A 3dcoB-2gjxA:
undetectable		 3dcoB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 3edlB-2gjxA:
undetectable		 3edlB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ASN A 199
ASP A 163
GLN A  28
 None
 0.78A 3eeyC-2gjxA:
undetectable		 3eeyC-2gjxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ASN A 199
ASP A 163
GLN A  28
 None
 0.78A 3eeyD-2gjxA:
undetectable		 3eeyD-2gjxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ASN A 199
ASP A 163
GLN A  28
 None
 0.79A 3eeyE-2gjxA:
undetectable		 3eeyE-2gjxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 VAL A 363
LYS A 368
HIS A 202
 None
 0.65A 3elzA-2gjxA:
undetectable		 3elzA-2gjxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 ASP A 386
TYR A 316
GLY A 367
SER A 364
 None
 0.76A 3ihzB-2gjxA:
undetectable		 3ihzB-2gjxA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.07A 3iz0B-2gjxA:
undetectable		 3iz0B-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.06A 3j6pB-2gjxA:
undetectable		 3j6pB-2gjxA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		10 / 12 ARG A 178
HIS A 204
ASP A 207
ASP A 258
HIS A 262
ASP A 322
TRP A 392
TYR A 421
TRP A 460
GLU A 462
 None
None
None
None
None
SO4  A 708 (-3.9A)
SO4  A 708 (-3.2A)
SO4  A 708 (-4.5A)
SO4  A 708 (-3.9A)
None
 0.25A 3lmyA-2gjxA:
56.5		 3lmyA-2gjxA:
56.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		12 / 12 ARG A 178
HIS A 204
ASP A 207
ASP A 258
HIS A 262
ASP A 322
GLU A 323
TRP A 373
TRP A 392
TYR A 421
TRP A 460
GLU A 462
 None
None
None
None
None
SO4  A 708 (-3.9A)
SO4  A 708 (-3.9A)
SO4  A 708 (-3.7A)
SO4  A 708 (-3.2A)
SO4  A 708 (-4.5A)
SO4  A 708 (-3.9A)
None
 0.36A 3lmyB-2gjxA:
56.4		 3lmyB-2gjxA:
56.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 HIS A 204
ASP A 258
TYR A 421
TRP A 460
GLU A 323
 None
None
SO4  A 708 (-4.5A)
SO4  A 708 (-3.9A)
SO4  A 708 (-3.9A)
 1.48A 3lmyB-2gjxA:
56.4		 3lmyB-2gjxA:
56.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 436
LEU A 517
LEU A 493
GLY A 478
ALA A 479
 None
 1.04A 3rr3C-2gjxA:
undetectable		 3rr3C-2gjxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 436
LEU A 517
LEU A 493
GLY A 478
ALA A 479
 None
 1.03A 3rr3D-2gjxA:
undetectable		 3rr3D-2gjxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_A_ACTA228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 4 ALA A  64
ARG A 249
TYR A  68
ARG A  67
 None
 1.39A 3touA-2gjxA:
0.0		 3touA-2gjxA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ARG A 166
PHE A 167
PRO A 168
 None
 0.79A 3zoaB-2gjxA:
12.0		 3zoaB-2gjxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 TYR A 116
THR A 141
GLU A 114
 None
 0.72A 4df3A-2gjxA:
undetectable		 4df3A-2gjxA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 TYR A 116
THR A 141
GLU A 114
 None
 0.70A 4df3B-2gjxA:
undetectable		 4df3B-2gjxA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 4 ASP A 433
GLY A 428
PRO A 429
GLN A 515
 None
 1.44A 4oltA-2gjxA:
0.0		 4oltA-2gjxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 10 PHE A 312
ALA A 255
VAL A 239
LEU A 183
PHE A 201
 None
 1.29A 4zmeB-2gjxA:
undetectable		 4zmeB-2gjxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 HIS A 204
HIS A 202
HIS A 318
LEU A 317
 None
 0.96A 5m8rB-2gjxA:
undetectable		 5m8rB-2gjxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 ASN A 379
THR A 387
GLN A 357
ILE A 356
 None
 0.93A 5nzxA-2gjxA:
undetectable		 5nzxA-2gjxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 7 ASN A 379
THR A 387
GLN A 357
ILE A 356
 None
 0.97A 5nzyA-2gjxA:
undetectable		 5nzyA-2gjxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.05A 5ogcB-2gjxA:
undetectable		 5ogcB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 LEU A 254
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 1.17A 5tudA-2gjxA:
undetectable		 5tudA-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 372
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 0.97A 5tudA-2gjxA:
undetectable		 5tudA-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 PHE A 305
PHE A 304
VAL A 290
LEU A 359
VAL A 363
 None
 1.28A 5tudD-2gjxA:
undetectable		 5tudD-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 VAL A 372
PHE A 305
PHE A 304
LEU A 359
VAL A 363
 None
 0.98A 5tudD-2gjxA:
undetectable		 5tudD-2gjxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 9 GLY A 455
LEU A 415
LEU A 317
VAL A 371
ILE A 453
 None
 0.97A 5vkqC-2gjxA:
undetectable
5vkqD-2gjxA:
undetectable		 5vkqC-2gjxA:
14.15
5vkqD-2gjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 GLY A 250
ASP A 314
VAL A 371
LEU A 415
SER A 112
 None
 1.18A 5vooA-2gjxA:
7.1		 5vooA-2gjxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 GLY A 250
ASP A 314
VAL A 371
LEU A 415
SER A 112
 None
 1.20A 5vooF-2gjxA:
10.3		 5vooF-2gjxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		5 / 12 LEU A 473
VAL A 437
ARG A 476
ASP A 430
ASP A 433
 None
 1.42A 6bxnA-2gjxA:
undetectable		 6bxnA-2gjxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 8 GLY A 138
LEU A 139
VAL A  60
LEU A  61
 None
 0.77A 6czmD-2gjxA:
undetectable
6czmF-2gjxA:
undetectable		 6czmD-2gjxA:
21.07
6czmF-2gjxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		3 / 3 LEU A 248
ASP A 188
ILE A 186
 None
 0.63A 6dh0B-2gjxA:
undetectable		 6dh0B-2gjxA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 5 ILE A 161
GLN A 144
THR A 141
THR A  32
 None
None
None
NAG  A   4 (-3.4A)
 1.14A 6f3mD-2gjxA:
undetectable		 6f3mD-2gjxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens) 		4 / 4 GLU A 256
ASP A 175
ARG A 178
TRP A 460
 None
None
None
SO4  A 708 (-3.9A)
 1.15A 6mn8A-2gjxA:
0.0		 6mn8A-2gjxA:
21.73