SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		5 / 9 ILE M 205
VAL N 509
GLY N 510
ALA N 486
LEU N 451
 None
 1.06A 1e7bA-2gk1M:
undetectable		 1e7bA-2gk1M:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 LEU I 416
LEU I 173
GLU I 394
TRP I 460
 None
None
None
NGT  A  21 (-3.7A)
 1.07A 1i7zA-2gk1I:
undetectable		 1i7zA-2gk1I:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 1jffB-2gk1I:
undetectable		 1jffB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 11 LEU I 172
VAL I 192
PRO I 471
LEU I 473
PRO I 475
 None
 1.22A 1klmA-2gk1I:
undetectable		 1klmA-2gk1I:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 ILE I 356
LEU I 359
VAL I 363
 None
 0.32A 1mz9B-2gk1I:
undetectable		 1mz9B-2gk1I:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 LEU I 273
TRP I 266
LEU I 221
PHE I 304
 None
 1.28A 1ru9H-2gk1I:
undetectable
1ru9L-2gk1I:
undetectable		 1ru9H-2gk1I:
17.80
1ru9L-2gk1I:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU M 305
TRP M 298
LEU M 254
PHE N 336
 None
 1.28A 1ru9H-2gk1M:
undetectable
1ru9L-2gk1M:
undetectable		 1ru9H-2gk1M:
21.43
1ru9L-2gk1M:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 LEU I 273
TRP I 266
LEU I 221
PHE I 304
 None
 1.26A 1rukH-2gk1I:
undetectable
1rukL-2gk1I:
undetectable		 1rukH-2gk1I:
17.80
1rukL-2gk1I:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU M 305
TRP M 298
LEU M 254
PHE N 336
 None
 1.26A 1rukH-2gk1M:
undetectable
1rukL-2gk1M:
undetectable		 1rukH-2gk1M:
21.43
1rukL-2gk1M:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLU M 288
HIS N 350
HIS M 235
GLU N 422
 None
 0.94A 1v7zA-2gk1M:
undetectable		 1v7zA-2gk1M:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLU M 288
HIS N 350
HIS M 235
GLU N 422
 None
 0.96A 1v7zD-2gk1M:
undetectable		 1v7zD-2gk1M:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLU M 288
HIS N 350
HIS M 235
GLU N 422
 None
 0.97A 1v7zE-2gk1M:
undetectable		 1v7zE-2gk1M:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLU M 288
HIS N 350
HIS M 235
GLU N 422
 None
 0.95A 1v7zF-2gk1M:
undetectable		 1v7zF-2gk1M:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 GLN I 106
ARG I 252
VAL I 100
VAL A  60
 None
 0.94A 2bdmA-2gk1I:
undetectable		 2bdmA-2gk1I:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 8 TYR N 526
TYR N 456
HIS I 179
GLY I 461
 None
 1.13A 2ha4A-2gk1N:
undetectable		 2ha4A-2gk1N:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR N 526
TYR N 456
HIS I 179
GLY I 461
 None
 1.13A 2ha4B-2gk1N:
undetectable		 2ha4B-2gk1N:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 2hxfB-2gk1I:
undetectable		 2hxfB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 2hxhB-2gk1I:
undetectable		 2hxhB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens) 		4 / 7 ARG N 501
ASP N 452
ILE I 425
GLN I 515
 None
 1.25A 2jc9A-2gk1N:
undetectable		 2jc9A-2gk1N:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 6 PRO M 215
HIS M 212
ASP M 240
TYR M 213
 None
 1.39A 2lh8A-2gk1M:
undetectable		 2lh8A-2gk1M:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 2p4nB-2gk1I:
undetectable		 2p4nB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 PHE A  65
ALA I 135
LEU I 136
ALA A  64
 None
 0.98A 2vcvB-2gk1A:
undetectable		 2vcvB-2gk1A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 GLY I 250
LEU I 127
VAL I  96
TYR A  48
SER A  52
 None
 1.08A 2vqyA-2gk1I:
undetectable		 2vqyA-2gk1I:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 2wbeB-2gk1I:
undetectable		 2wbeB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 VAL I 512
ASN I 196
TRP A  24
 None
 1.11A 2y00B-2gk1I:
undetectable		 2y00B-2gk1I:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 PHE I 304
PHE I 257
GLU I 307
GLU I 214
PHE I 211
 None
 1.48A 3apxA-2gk1I:
undetectable		 3apxA-2gk1I:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 5 HIS I 204
ASP I 258
HIS I 262
ASP I 322
 None
None
NGT  A  21 (-3.4A)
NGT  A  21 (-3.2A)
 1.22A 3c0zA-2gk1I:
undetectable		 3c0zA-2gk1I:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 5 HIS M 237
ASP M 290
HIS M 294
ASP N 354
 None
 1.17A 3c0zA-2gk1M:
undetectable		 3c0zA-2gk1M:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.12A 3dcoB-2gk1I:
undetectable		 3dcoB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.10A 3edlB-2gk1I:
undetectable		 3edlB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN I 199
ASP I 163
GLN A  28
 None
 0.83A 3eeyC-2gk1I:
undetectable		 3eeyC-2gk1I:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN I 199
ASP I 163
GLN A  28
 None
 0.84A 3eeyD-2gk1I:
undetectable		 3eeyD-2gk1I:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 VAL I 363
LYS I 368
HIS I 202
 None
 0.70A 3elzA-2gk1I:
undetectable		 3elzA-2gk1I:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.81A 3fi0B-2gk1M:
undetectable		 3fi0B-2gk1M:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 7 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.88A 3fi0E-2gk1M:
undetectable		 3fi0E-2gk1M:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.76A 3fi0I-2gk1M:
undetectable		 3fi0I-2gk1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 GLY I 138
ASP I 163
ILE I 161
GLN I 144
 None
 0.93A 3fi0P-2gk1I:
undetectable		 3fi0P-2gk1I:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 7 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.74A 3fi0P-2gk1M:
undetectable		 3fi0P-2gk1M:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE A  65
GLY I 138
SER I 143
ILE I 161
THR I 159
 None
 1.31A 3iv6A-2gk1A:
undetectable		 3iv6A-2gk1A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.11A 3iz0B-2gk1I:
undetectable		 3iz0B-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.10A 3j6pB-2gk1I:
undetectable		 3j6pB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLU M 173
ASN M 229
HIS N 532
MET N 536
 None
 0.87A 3kp6A-2gk1M:
undetectable
3kp6B-2gk1M:
undetectable		 3kp6A-2gk1M:
24.38
3kp6B-2gk1M:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		10 / 12 ARG I 178
HIS I 204
ASP I 207
ASP I 258
HIS I 262
ASP I 322
TRP I 392
TYR I 421
TRP I 460
GLU I 462
 NGT  A  21 (-2.3A)
None
NGT  A  21 (-3.8A)
None
NGT  A  21 (-3.4A)
NGT  A  21 (-3.2A)
NGT  A  21 ( 4.3A)
None
NGT  A  21 (-3.7A)
NGT  A  21 (-3.0A)
 0.25A 3lmyA-2gk1I:
54.2		 3lmyA-2gk1I:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		12 / 12 ARG M 211
HIS M 237
ASP M 240
ASP M 290
HIS M 294
ASP N 354
TRP N 424
TYR N 450
ASP N 452
LEU N 453
TRP N 489
GLU N 491
 None
 0.35A 3lmyA-2gk1M:
12.6		 3lmyA-2gk1M:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		12 / 12 ARG I 178
HIS I 204
ASP I 207
ASP I 258
HIS I 262
ASP I 322
GLU I 323
TRP I 373
TRP I 392
TYR I 421
TRP I 460
GLU I 462
 NGT  A  21 (-2.3A)
None
NGT  A  21 (-3.8A)
None
NGT  A  21 (-3.4A)
NGT  A  21 (-3.2A)
NGT  A  21 (-3.4A)
NGT  A  21 (-3.0A)
NGT  A  21 ( 4.3A)
None
NGT  A  21 (-3.7A)
NGT  A  21 (-3.0A)
 0.33A 3lmyB-2gk1I:
54.1		 3lmyB-2gk1I:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 ASP I 208
HIS I 262
ASP I 322
GLU I 323
TRP I 392
 None
NGT  A  21 (-3.4A)
NGT  A  21 (-3.2A)
NGT  A  21 (-3.4A)
NGT  A  21 ( 4.3A)
 1.32A 3lmyB-2gk1I:
54.1		 3lmyB-2gk1I:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 HIS I 204
ASP I 207
GLU I 462
TYR I 421
TRP I 460
 None
NGT  A  21 (-3.8A)
NGT  A  21 (-3.0A)
None
NGT  A  21 (-3.7A)
 1.33A 3lmyB-2gk1I:
54.1		 3lmyB-2gk1I:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		12 / 12 ARG M 211
HIS M 237
ASP M 240
ASP M 290
HIS M 294
ASP N 354
GLU N 355
TRP N 405
TRP N 424
TYR N 450
TRP N 489
GLU N 491
 None
 0.40A 3lmyB-2gk1M:
19.3		 3lmyB-2gk1M:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 8 GLY M 299
LEU M 305
LEU M 306
ILE N 322
 None
 0.78A 3nbqC-2gk1M:
undetectable		 3nbqC-2gk1M:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 4 SER I 129
GLY I 250
GLU I 244
 None
 0.64A 3raeA-2gk1I:
undetectable
3raeC-2gk1I:
undetectable		 3raeA-2gk1I:
21.90
3raeC-2gk1I:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 5 LEU N 469
PHE N 481
PHE M 200
ARG M 199
 None
 1.11A 3smtA-2gk1N:
undetectable		 3smtA-2gk1N:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_A_ACTA228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ALA A  64
ARG I 249
TYR A  68
ARG A  67
 None
 1.31A 3touA-2gk1A:
undetectable		 3touA-2gk1A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_B_ACTB228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ALA A  64
ARG I 249
TYR A  68
ARG A  67
 None
 1.29A 3touB-2gk1A:
undetectable		 3touB-2gk1A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 PRO I 209
ASP I 207
GLU I 462
 None
NGT  A  21 (-3.8A)
NGT  A  21 (-3.0A)
 0.77A 3v4tC-2gk1I:
undetectable		 3v4tC-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 HIS I 262
ASP I 395
ASP I 322
GLU I 394
 NGT  A  21 (-3.4A)
None
NGT  A  21 (-3.2A)
None
 1.25A 3vywA-2gk1I:
undetectable		 3vywA-2gk1I:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLY N 352
GLU M 288
ASP M 208
GLU N 491
 None
 1.00A 3vywC-2gk1N:
undetectable		 3vywC-2gk1N:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 ARG I 166
PHE I 167
PRO I 168
 None
 0.81A 3zoaB-2gk1I:
12.3		 3zoaB-2gk1I:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 TYR I 116
THR I 141
GLU I 114
 None
 0.76A 4df3A-2gk1I:
undetectable		 4df3A-2gk1I:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		3 / 3 TYR M 149
THR M 174
GLU M 147
 None
 0.71A 4df3A-2gk1M:
undetectable		 4df3A-2gk1M:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 TYR I 116
THR I 141
GLU I 114
 None
 0.74A 4df3B-2gk1I:
undetectable		 4df3B-2gk1I:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		3 / 3 TYR M 149
THR M 174
GLU M 147
 None
 0.71A 4df3B-2gk1M:
undetectable		 4df3B-2gk1M:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 5 GLU M 147
SER M 148
PRO M 198
SER M 197
 None
 1.25A 4k17B-2gk1M:
2.0		 4k17B-2gk1M:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		4 / 6 GLU N 357
ASP N 354
ASP M 290
ARG M 211
 None
 0.89A 4ntxA-2gk1N:
2.1
4ntxC-2gk1N:
undetectable		 4ntxA-2gk1N:
19.50
4ntxC-2gk1N:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens) 		3 / 3 ASP N 452
TYR I 427
TRP N 489
 None
 1.31A 4p7nA-2gk1N:
4.5		 4p7nA-2gk1N:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 PRO I 471
VAL I 464
HIS I 179
 None
 0.80A 4pevC-2gk1I:
undetectable		 4pevC-2gk1I:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		3 / 3 PRO N 500
VAL N 493
HIS M 212
 None
 0.64A 4pevC-2gk1N:
undetectable		 4pevC-2gk1N:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		5 / 8 LEU N 351
GLY N 352
GLU M 288
GLU N 485
GLU N 422
 None
 1.44A 4rjdA-2gk1N:
undetectable
4rjdB-2gk1N:
undetectable		 4rjdA-2gk1N:
13.30
4rjdB-2gk1N:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens) 		5 / 12 LEU N 451
ALA N 506
VAL N 509
GLY M 204
GLY N 484
 None
 1.02A 4rn6B-2gk1N:
undetectable		 4rn6B-2gk1N:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens) 		3 / 3 VAL N 443
PHE N 409
ARG N 435
 None
 0.95A 4xr4B-2gk1N:
undetectable		 4xr4B-2gk1N:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 PHE I 312
ALA I 255
VAL I 239
LEU I 183
PHE I 201
 None
 1.27A 4zmeB-2gk1I:
undetectable		 4zmeB-2gk1I:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 TYR N 456
GLY I 461
GLU I 462
ASP I 207
 None
None
NGT  A  21 (-3.0A)
NGT  A  21 (-3.8A)
 1.00A 5emlA-2gk1N:
4.0		 5emlA-2gk1N:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 6 TYR I 427
GLY N 490
GLU N 491
ASP M 240
 None
 1.17A 5emlA-2gk1I:
4.0		 5emlA-2gk1I:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG N 533
THR I 467
ASP I 465
 None
 0.95A 5g5gA-2gk1N:
undetectable
5g5gB-2gk1N:
undetectable		 5g5gA-2gk1N:
19.16
5g5gB-2gk1N:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 6 TYR A  68
ILE I 251
ARG I 249
TYR I 245
 None
 1.47A 5igyA-2gk1A:
undetectable		 5igyA-2gk1A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ASP I 175
ARG I 424
TYR N 456
TYR N 547
 None
 1.09A 5igyA-2gk1I:
undetectable		 5igyA-2gk1I:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ASP I 175
ARG I 424
TYR N 456
TYR N 547
 None
 1.13A 5iwuA-2gk1I:
undetectable		 5iwuA-2gk1I:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 ILE I 186
VAL I 253
TYR I 245
VAL I 242
 None
 0.99A 5jwaH-2gk1I:
undetectable		 5jwaH-2gk1I:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 HIS I 204
HIS I 202
HIS I 318
LEU I 317
 None
 0.95A 5m8rA-2gk1I:
undetectable		 5m8rA-2gk1I:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 HIS I 204
HIS I 202
HIS I 318
LEU I 317
 None
 0.91A 5m8rB-2gk1I:
undetectable		 5m8rB-2gk1I:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 HIS I 204
HIS I 202
HIS I 318
LEU I 317
 None
 0.91A 5m8rD-2gk1I:
undetectable		 5m8rD-2gk1I:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 4 ASN I 196
SER I 486
ALA I 481
VAL I 480
 None
 1.37A 5nm5A-2gk1I:
2.2		 5nm5A-2gk1I:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens) 		4 / 8 ILE N 349
LEU N 351
ILE N 395
ILE N 398
 None
 0.71A 5numA-2gk1N:
undetectable		 5numA-2gk1N:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 ASN I 379
THR I 387
GLN I 357
ILE I 356
 None
 0.90A 5nzxA-2gk1I:
undetectable		 5nzxA-2gk1I:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 ASN I 379
THR I 387
GLN I 357
ILE I 356
 None
 0.94A 5nzyA-2gk1I:
undetectable		 5nzyA-2gk1I:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.09A 5ogcB-2gk1I:
undetectable		 5ogcB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 LEU I 254
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 1.16A 5tudA-2gk1I:
undetectable		 5tudA-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 372
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 0.95A 5tudA-2gk1I:
undetectable		 5tudA-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 VAL I 372
PHE I 305
PHE I 304
LEU I 359
VAL I 363
 None
 0.96A 5tudD-2gk1I:
undetectable		 5tudD-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 ARG I 247
GLU I 244
LEU I 136
ARG A  67
 None
 1.01A 5umwB-2gk1I:
undetectable
5umwE-2gk1I:
undetectable		 5umwB-2gk1I:
11.36
5umwE-2gk1I:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 9 GLY I 455
LEU I 415
LEU I 317
VAL I 371
ILE I 453
 None
 0.96A 5vkqC-2gk1I:
undetectable
5vkqD-2gk1I:
undetectable		 5vkqC-2gk1I:
12.94
5vkqD-2gk1I:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 GLY I 250
ASP I 314
VAL I 371
LEU I 415
SER I 112
 None
 1.20A 5vooA-2gk1I:
7.0		 5vooA-2gk1I:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 LEU I 319
PHE I 257
PHE I 305
LEU I 359
 None
 1.18A 5x19P-2gk1I:
undetectable		 5x19P-2gk1I:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens) 		5 / 7 ALA N 413
PHE N 337
ILE N 395
LEU N 392
ILE N 322
 None
 1.48A 6b5vA-2gk1N:
undetectable
6b5vB-2gk1N:
undetectable		 6b5vA-2gk1N:
14.83
6b5vB-2gk1N:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY I 138
LEU I 139
VAL A  60
LEU A  61
 None
 0.69A 6czmD-2gk1I:
undetectable
6czmF-2gk1I:
undetectable		 6czmD-2gk1I:
20.97
6czmF-2gk1I:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 5 ILE I 161
GLN I 144
THR I 141
THR A  32
 None
None
None
NAG  A   4 (-4.0A)
 1.10A 6f3mD-2gk1I:
undetectable		 6f3mD-2gk1I:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 4 GLU I 256
ASP I 175
ARG I 178
TRP I 460
 None
None
NGT  A  21 (-2.3A)
NGT  A  21 (-3.7A)
 1.11A 6mn8A-2gk1I:
0.0		 6mn8A-2gk1I:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens) 		4 / 4 GLU M 288
ASP M 208
ARG M 211
TRP N 489
 None
 1.10A 6mn8A-2gk1M:
0.0		 6mn8A-2gk1M:
16.54