SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 ILE A  13
ILE A 250
ILE A 108
LEU A  46
 None
 0.86A 1zgyA-2gk3A:
undetectable		 1zgyA-2gk3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 SER A 126
ASP A  82
SER A  81
ASN A 187
 None
GOL  A1001 (-3.4A)
None
None
 1.10A 2cmlA-2gk3A:
undetectable		 2cmlA-2gk3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 8 SER A 126
ASP A  82
SER A  81
ASN A 187
 None
GOL  A1001 (-3.4A)
None
None
 1.02A 2cmlC-2gk3A:
undetectable		 2cmlC-2gk3A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 TYR A 186
VAL A 190
VAL A 197
VAL A 208
 None
 0.87A 2qbnA-2gk3A:
undetectable		 2qbnA-2gk3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 TYR A 111
VAL A  10
TYR A  75
ILE A  13
 None
 1.22A 2xz5B-2gk3A:
undetectable
2xz5E-2gk3A:
undetectable		 2xz5B-2gk3A:
20.61
2xz5E-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 8 ILE A  13
TYR A 111
VAL A  10
TYR A  75
 None
 1.22A 2xz5A-2gk3A:
undetectable
2xz5C-2gk3A:
undetectable		 2xz5A-2gk3A:
20.61
2xz5C-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 8 ILE A  13
TYR A 111
VAL A  10
TYR A  75
 None
 1.24A 2xz5C-2gk3A:
undetectable
2xz5D-2gk3A:
undetectable		 2xz5C-2gk3A:
20.61
2xz5D-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ILE A  13
TYR A 111
VAL A  10
TYR A  75
 None
 1.23A 2xz5D-2gk3A:
undetectable
2xz5E-2gk3A:
undetectable		 2xz5D-2gk3A:
20.61
2xz5E-2gk3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 PHE A 220
TYR A 186
LEU A 118
 None
 0.76A 3sueB-2gk3A:
undetectable		 3sueB-2gk3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A 123
VAL A 156
ASP A 154
GLY A  84
ALA A 134
 GOL  A1001 ( 4.2A)
None
None
None
None
 1.02A 3sugA-2gk3A:
undetectable		 3sugA-2gk3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A 130
GLY A 129
ASN A 187
GLU A 157
GLY A 122
 None
 0.98A 3uboA-2gk3A:
3.8		 3uboA-2gk3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 ILE A  13
ALA A 104
MET A  56
PHE A  88
 None
 0.76A 4dc3B-2gk3A:
3.6		 4dc3B-2gk3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 10 PHE A 209
ALA A 218
VAL A 173
LEU A 199
PHE A 220
 None
 1.35A 4zmeB-2gk3A:
undetectable		 4zmeB-2gk3A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 TYR A 212
LYS A 113
LYS A 109
 None
 1.26A 5dbyA-2gk3A:
undetectable		 5dbyA-2gk3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ILE A  13
GLY A  14
LEU A 207
PHE A 209
 None
 0.90A 5hieB-2gk3A:
undetectable		 5hieB-2gk3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 GLU A 131
LEU A  90
THR A  87
GLY A 129
LEU A 125
 None
 1.29A 5ogcB-2gk3A:
2.6		 5ogcB-2gk3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 GLU A 143
TYR A 212
GLY A 215
GLY A 115
 None
 0.97A 5x7pB-2gk3A:
undetectable		 5x7pB-2gk3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2gk3 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A  80
ILE A 121
ASP A 223
ASP A  82
ILE A  83
 None
None
GOL  A1001 (-3.6A)
GOL  A1001 (-3.4A)
None
 0.83A 6emuA-2gk3A:
undetectable		 6emuA-2gk3A:
21.03