SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LYS A 158
LEU A 160
ALA A 186
VAL A 202
 None
 0.70A 1sn5A-2gk4A:
undetectable		 1sn5A-2gk4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 168
ILE A 184
VAL A 202
ALA A 186
 None
 1.08A 2j5mA-2gk4A:
undetectable		 2j5mA-2gk4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ASP A 182
ILE A 142
GLY A 156
ILE A 185
VAL A  84
 None
 1.27A 3ekyB-2gk4A:
undetectable		 3ekyB-2gk4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LYS A 158
LEU A 160
ALA A 186
VAL A 202
 None
 0.73A 3ozkB-2gk4A:
undetectable		 3ozkB-2gk4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 GLY A  26
GLY A   8
THR A  47
LEU A  45
 None
 0.91A 3si7C-2gk4A:
1.2
3si7D-2gk4A:
undetectable		 3si7C-2gk4A:
23.37
3si7D-2gk4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 LYS A 158
LEU A 160
ALA A 186
VAL A 202
 None
 1.16A 4ik6A-2gk4A:
0.0		 4ik6A-2gk4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A 158
LEU A 160
ALA A 186
 None
 0.68A 4ikiA-2gk4A:
undetectable		 4ikiA-2gk4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLY A  26
LEU A  52
HIS A  27
 None
 0.67A 5u63A-2gk4A:
4.6		 5u63A-2gk4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLY A  26
LEU A  52
HIS A  27
 None
 0.67A 5u63B-2gk4A:
4.3		 5u63B-2gk4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A 197
GLY A  29
GLY A  26
ALA A  51
ILE A  86
 GOL  A 501 (-4.7A)
None
None
None
None
 1.09A 6b3aA-2gk4A:
3.1		 6b3aA-2gk4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A 197
GLY A  29
GLY A  26
ALA A  51
ILE A  86
 GOL  A 501 (-4.7A)
None
None
None
None
 1.12A 6b3bA-2gk4A:
3.1		 6b3bA-2gk4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2gk4 CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ALA A 199
ILE A  31
PHE A 157
LEU A  28
 None
None
GOL  A 501 (-4.0A)
GOL  A 501 ( 4.7A)
 0.84A 6b5vA-2gk4A:
undetectable
6b5vB-2gk4A:
undetectable		 6b5vA-2gk4A:
14.59
6b5vB-2gk4A:
14.59